Protein: BCAR3
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)

Gene: BCAR3
Organism: Homo sapiens
Interactions: 102
UniProt ID: O75815

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002089 - lens morphogenesis in camera-type eye
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

294847

BCAR1
Breast cancer anti-estrogen resistance protein 1

5

20

Small-scale

0.937

High

294859

CASL
Enhancer of filamentation 1

4

20

Small-scale

0.910

High

294825

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

294809

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.755

High

294839

CRK
Adapter molecule crk

2

20

High-throughput

0.737

High

294815

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

294817

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

294811

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

294862

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

294832

IRS1
Insulin receptor substrate 1

2

20

High-throughput

0.634

High

294808

ABL1
Tyrosine-protein kinase ABL1

1

19

High-throughput

0.618

High

294838

ABL2
Tyrosine-protein kinase ABL2

1

19

High-throughput

0.618

High

294871

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

294881

LRC59
Leucine-rich repeat-containing protein 59

1

7

High-throughput

0.618

High

294848

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

20

High-throughput

0.606

High

294866

CCD57
Coiled-coil domain-containing protein 57

2

20

High-throughput

0.606

High

294888

AP1M1
AP-1 complex subunit mu-1

2

5

High-throughput

0.606

High

294810

GAST
Gastrin [Cleaved into: Gastrin-71

2

0

High-throughput

0.602

High

294803

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

20

High-throughput

0.590

High

294806

DRC4
Dynein regulatory complex subunit 4

2

1

High-throughput

0.553

High

294833

FUS
RNA-binding protein FUS

2

9

High-throughput

0.549

High

294820

CCL5
C-C motif chemokine 5

1

3

High-throughput

0.541

High

294834

SPB5
Serpin B5

1

11

High-throughput

0.541

High

294844

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.541

High

294886

MTA3
Metastasis-associated protein MTA3

1

3

High-throughput

0.541

High

294889

BEX2
Protein BEX2

1

2

High-throughput

0.541

High

294892

BEX1
Protein BEX1

1

2

High-throughput

0.541

High

294894

VPS45
Vacuolar protein sorting-associated protein 45

1

3

High-throughput

0.541

High

294898

ERRFI
ERBB receptor feedback inhibitor 1

1

20

High-throughput

0.541

High

294858

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

294878

MY18A
Unconventional myosin-XVIIIa

1

20

High-throughput

0.536

High

294893

PCDBG
Protocadherin beta-16

1

12

High-throughput

0.536

High

294804

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.518

High

294867

GREB1
Protein GREB1

1

0

High-throughput

0.518

High

294877

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.518

High

294818

PABP1
Polyadenylate-binding protein 1

1

7

High-throughput

0.515

High

294819

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.515

High

294822

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

294887

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.513

High

294895

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

294812

A4
Amyloid-beta precursor protein

1

18

High-throughput

0.501

High

294816

HXC6
Homeobox protein Hox-C6

1

9

High-throughput

0.494

High

294865

CYTM
Cystatin-M

1

2

High-throughput

0.494

High

294870

ATAD2
ATPase family AAA domain-containing protein 2

1

5

High-throughput

0.494

High

294876

AGR3
Anterior gradient protein 3

1

4

High-throughput

0.494

High

294883

PDLI2
PDZ and LIM domain protein 2

1

20

High-throughput

0.494

High

294884

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

3

High-throughput

0.494

High

294890

NSD3
Histone-lysine N-methyltransferase NSD3

1

14

High-throughput

0.494

High

294891

PRD14
PR domain zinc finger protein 14

1

3

High-throughput

0.494

High

294874

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

5

High-throughput

0.489

High

294814

ANXA2
Annexin A2

1

10

High-throughput

0.479

High

294821

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

4

High-throughput

0.479

High

294824

LMNB1
Lamin-B1

1

20

High-throughput

0.479

High

294827

PSA2
Proteasome subunit alpha type-2

1

3

High-throughput

0.479

High

294829

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

294830

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.479

High

294831

KINH
Kinesin-1 heavy chain

1

3

High-throughput

0.479

High

294835

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

294837

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

294840

PAXI
Paxillin

1

20

High-throughput

0.479

High

294841

NASP
Nuclear autoantigenic sperm protein

1

2

High-throughput

0.479

High

294843

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.479

High

294845

ACLY
ATP-citrate synthase

1

2

High-throughput

0.479

High

294846

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

294849

ARP2
Actin-related protein 2

1

13

High-throughput

0.479

High

294851

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

294852

SET
Protein SET

1

2

High-throughput

0.479

High

294854

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.479

High

294855

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

294856

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

294861

KIF14
Kinesin-like protein KIF14

1

15

High-throughput

0.479

High

294863

PCBP1
Poly(rC)-binding protein 1

1

19

High-throughput

0.479

High

294864

TSN
Translin

1

2

High-throughput

0.479

High

294868

Q5T081
Regulator of chromosome condensation

1

2

High-throughput

0.479

High

294875

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

294880

FUBP2
Far upstream element-binding protein 2

1

20

High-throughput

0.479

High

294885

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

294900

RUVB1
RuvB-like 1

1

5

High-throughput

0.479

High

294828

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

3

High-throughput

0.470

High

176629

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.458

High

294823

PYRG1
CTP synthase 1

1

0

High-throughput

0.458

High

294850

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

294901

NOSIP
Nitric oxide synthase-interacting protein

1

0

High-throughput

0.458

High

253926

LPXN
Leupaxin

1

20

High-throughput

0.445

High

294805

RTN3
Reticulon-3

1

4

High-throughput

0.437

High

294807

AATM
Aspartate aminotransferase, mitochondrial

1

1

High-throughput

0.437

High

294813

TPM3
Tropomyosin alpha-3 chain

1

5

High-throughput

0.437

High

294826

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.437

High

294836

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

4

High-throughput

0.437

High

294857

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.437

High

294860

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

294899

OSGI1
Oxidative stress-induced growth inhibitor 1

3

0

High-throughput

0.348

High

294853

DEF5
Defensin alpha 5

2

0

High-throughput

0.328

High

294872

CASZ1
Zinc finger protein castor homolog 1

1

0

High-throughput

0.282

High

294879

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.282

High

294882

ESIP1
Epithelial-stromal interaction protein 1

1

0

High-throughput

0.282

High

294896

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.282

High

294897

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.282

High

294842

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.279

Low

294873

CCD25
Coiled-coil domain-containing protein 25

1

0

High-throughput

0.279

Low

294869

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025