HitPredict

Interactor 1: PBX3 (O35317)
Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)
Gene: PBX3

Interactor 2: HXD10 (P28359)
Homeobox protein Hox-D10 (Homeobox protein Hox-4.5) (Homeobox protein Hox-5.3)
Gene: Hoxd10

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0008344 - adult locomotory behavior GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 434 Mm			1 340
+	Mm
		204669 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXC6_MOUSE (130-325): 1.8e-34: 128: 26.50
+	Mm
		204664 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXB5_MOUSE (138-339): 5.25e-32: 122: 28.78
+	Hs
		604773 PBX3_HUMAN (1-434): 7.6e-156: 449: 99.77		HXB8_HUMAN (141-334): 3.32e-31: 119: 30.00
+	Mm
		204665 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXA6_MOUSE (129-326): 1.82e-31: 119: 25.60
+	Mm
		204668 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXD4_MOUSE (130-326): 1.29e-30: 118: 23.62
+	Mm
		204667 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXB8_MOUSE (141-334): 2.44e-30: 117: 30.00
+	Hs
		724990 PBX3_HUMAN (1-434): 7.6e-156: 449: 99.77		HXA9_HUMAN (109-328): 8.19e-30: 116: 29.17
+	Mm
		204666 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXA9_MOUSE (106-328): 7.15e-30: 116: 28.93
+	Mm
		204672 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXC5_MOUSE (127-333): 7.51e-30: 115: 27.96
+	Mm
		204670 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		HXD9_MOUSE (254-318): 3.96e-25: 105: 73.85
+	Hs
		724922 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXA10_HUMAN (5-340): 1.11e-42: 154: 39.64
+	Hs
		725025 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXC8_HUMAN (149-331): 4.83e-37: 134: 27.84
+	Hs
		574042 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXB1_HUMAN (77-328): 8.04e-33: 125: 23.49
+	Hs
		478660 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXB5_HUMAN (138-339): 6.33e-33: 124: 29.76
+	Hs
		478283 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXD4_HUMAN (130-326): 4.9e-32: 122: 23.88
+	Hs
		604772 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXB8_HUMAN (141-334): 3.32e-31: 119: 30.00
+	Hs
		184763 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		SHOX_HUMAN (187-328): 8.9e-30: 117: 22.92
+	Hs
		484820 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXB7_HUMAN (128-326): 9.4e-31: 117: 26.70
+	Hs
		724988 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXA9_HUMAN (109-328): 8.19e-30: 116: 29.17
+	Hs
		703235 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		HXD9_HUMAN (254-318): 3.47e-24: 103: 73.85