HitPredict

Interactor 1: PK3CD (O35904)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: Pik3cd

Interactor 2: RASK (P32883)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: Kras

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23706742
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1043 Mm			1 189
+	Mm
		205655 PK3CD_MOUSE (1-1043): 0: 1306: 100.00		RASN_MOUSE (1-189): 1.16e-86: 254: 86.77
+	Mm
		205662 PK3CD_MOUSE (1-1043): 0: 1306: 100.00		RASH_MOUSE (1-188): 8.01e-87: 254: 86.77
+	Hs
		132783 PK3CD_HUMAN (1-1043): 0: 1293: 94.35		RASH_HUMAN (1-188): 8.01e-87: 254: 86.77
+	Mm
		205661 PK3CD_MOUSE (1-1043): 0: 1306: 100.00		RRAS2_MOUSE (3-188): 1.47e-54: 173: 54.12
+	Mm
		1222729 PK3CB_MOUSE (1-1042): 0: 1137: 55.39		RASH_MOUSE (1-188): 8.01e-87: 254: 86.77
+	Hs
		375261 PK3CB_HUMAN (1-1042): 0: 1110: 55.30		RASK_HUMAN (16-189): 8.56e-79: 234: 98.85
+	Mm
		470808 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RASN_MOUSE (1-189): 1.16e-86: 254: 86.77
+	Mm
		839128 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RASH_MOUSE (1-188): 8.01e-87: 254: 86.77
+	Hs
		374446 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RASH_HUMAN (1-188): 8.01e-87: 254: 86.77
+	Hs
		373816 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RASN_HUMAN (1-189): 7.32e-86: 252: 86.24
+	Mm
		746557 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RASK_MOUSE (16-189): 3.42e-79: 235: 100.00
+	Hs
		375260 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RASK_HUMAN (16-189): 8.56e-79: 234: 98.85
+	Hs
		839021 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RB11B_HUMAN (4-175): 9.93e-76: 228: 34.48
+	Dm
		473597 P91634_DROME (9-1043): 0: 1004: 38.38		RAS1_DROME (1-165): 3e-88: 258: 86.06
+	Mm
		839125 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RRAS2_MOUSE (3-188): 1.47e-54: 173: 54.12
+	Hs
		374461 PK3CG_HUMAN (16-1037): 0: 953: 30.66		RASH_HUMAN (1-188): 8.01e-87: 254: 86.77
+	Hs
		373831 PK3CG_HUMAN (16-1037): 0: 953: 30.66		RASN_HUMAN (1-189): 7.32e-86: 252: 86.24
+	Mm
		470810 PK3CG_MOUSE (1-1037): 0: 949: 30.30		RASN_MOUSE (1-189): 1.16e-86: 254: 86.77
+	Hs
		375287 PK3CG_HUMAN (16-1037): 0: 953: 30.66		RASK_HUMAN (16-189): 8.56e-79: 234: 98.85
+	Dm
		408498 P91634_DROME (9-1043): 0: 1004: 38.38		RAS2_DROME (1-189): 3.39e-55: 174: 54.92