HitPredict

Interactor 1: MED7 (O43513)
Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33)
Gene: MED7

Interactor 2: MED13 (Q9UHV7)
Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
Gene: MED13

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.735

Property	Details
Experiments	26186194, 28514442, 24981860, 33961781, 29568061, 23563140
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:0060261 - positive regulation of transcription initiation by RNA polymerase II
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 2174
+	Hs
		206629 MED7_HUMAN (1-233): 4.09e-115: 330: 100.00		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Dm
		1182287 MED7_DROME (3-229): 3.95e-77: 233: 50.00		MED13_DROME (776-947): 6.01e-50: 198: 25.11