HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	32640226, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1360
+	Hs
		557820 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		209112 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		557740 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		208968 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		324734 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Mm
		956970 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		M4K4_MOUSE (1-1360): 0: 946: 58.91
+	Hs
		209164 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		SIK2_HUMAN (15-915): 3.97e-124: 410: 14.70
+	Hs
		557731 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K3_HUMAN (13-371): 3.79e-108: 365: 40.33
+	Dm
		1182596 NCK_DROME (6-377): 1.75e-68: 226: 39.90		Q7KV88_DROME (3-772): 2.56e-123: 412: 41.74
+	Ce
		1095301 Q95PW9_CAEEL (1-379): 5.2e-75: 239: 37.88		MIG15_CAEEL (6-722): 1.6e-113: 385: 37.98
+	Hs
		655378 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		412203 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		782836 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		MAST1_HUMAN (2-1051): 2.7e-124: 424: 14.80
+	Hs
		557840 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Hs
		655279 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		412095 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		655461 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		SIK2_HUMAN (15-915): 3.97e-124: 410: 14.70
+	Hs
		412163 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		STK4_HUMAN (5-482): 7.72e-121: 387: 33.06
+	Hs
		1217590 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		M4K3_HUMAN (13-371): 3.79e-108: 365: 40.33
+	Hs
		412205 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63