HitPredict

Interactor 1: STX6 (O43752)
Syntaxin-6
Gene: STX6

Interactor 2: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	34079125, 28514442, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0000139 - Golgi membrane GO:0005484 - SNAP receptor activity GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 215
+	Hs
		235130 STX10_HUMAN (1-239): 5.84e-67: 209: 61.09		SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00
+	Hs
		212772 STX6_HUMAN (1-239): 4.31e-68: 212: 100.00		VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62
+	Hs
		263392 STX8_HUMAN (3-236): 1.15e-36: 131: 17.45		SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00
+	Hs
		169333 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00
+	Hs
		180766 STX6_HUMAN (1-239): 4.31e-68: 212: 100.00		YKT6_HUMAN (30-188): 3.07e-53: 171: 23.13
+	Dm
		115843 Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29		M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22
+	Hs
		850607 STX8_HUMAN (3-236): 1.15e-36: 131: 17.45		VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62
+	Sc
		605870 TLG1_YEAST (2-238): 4.64e-31: 116: 16.46		SEC22_YEAST (1-215): 1.97e-66: 205: 35.65
+	Dm
		115845 Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93		M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22
+	Hs
		169416 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62
+	Hs
		180956 STX8_HUMAN (3-236): 1.15e-36: 131: 17.45		YKT6_HUMAN (30-188): 3.07e-53: 171: 23.13
+	Dm
		1178135 Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29		Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54
+	Rn
		1125559 BET1_RAT (138-255): 4.29e-34: 121: 16.95		YKT6_RAT (30-188): 8.16e-53: 170: 23.13
+	Hs
		169321 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		YKT6_HUMAN (30-188): 3.07e-53: 171: 23.13
+	Mm
		193165 BET1_MOUSE (138-255): 2.32e-34: 121: 16.95		YKT6_MOUSE (30-188): 1.21e-52: 169: 23.13
+	Dm
		1178137 Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93		Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54
+	Sc
		731077 TLG1_YEAST (2-238): 4.64e-31: 116: 16.46		YKT6_YEAST (31-188): 1.64e-44: 148: 24.54
+	Rn
		192329 BET1L_RAT (155-253): 7.48e-20: 83.8: 17.00		YKT6_RAT (30-188): 8.16e-53: 170: 23.13
+	Dm
		1374685 Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29		Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25
+	Dm
		1374918 Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93		Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25