HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	25274033, 30244836, 33158056, 24508459, 19762545
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 920
+	Hs
		214020 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		214030 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		214106 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		RXRB_HUMAN (508-902): 1.59e-105: 339: 21.47
+	Hs
		659722 SPOPL_HUMAN (1-374): 1.16e-118: 350: 80.36		RXRB_HUMAN (508-902): 1.59e-105: 339: 21.47
+	Hs
		1120792 KLH12_HUMAN (180-373): 2.62e-64: 216: 22.68		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		377784 KLHL3_HUMAN (152-371): 2.59e-59: 203: 22.73		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		1049287 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		611438 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		NR4A1_HUMAN (410-905): 1.85e-106: 343: 18.71
+	Dm
		1259329 RDX_DROME (1-374): 5.65e-111: 344: 79.41		Q8WS79_DROME (557-788): 7.93e-28: 120: 29.41
+	Dm
		1365583 RDX_DROME (1-374): 5.65e-111: 344: 79.41		Q9VSE9_DROME (557-788): 6.94e-28: 120: 29.41
+	Hs
		659742 KLH11_HUMAN (199-328): 4.53e-13: 72.4: 31.21		RXRB_HUMAN (508-902): 1.59e-105: 339: 21.47