HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.707

Property	Details
Experiments	28805820, 28805822, 31026449, 28805821
Identification Methods	affinity chromatography technology, pull down, two hybrid, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 726
+	Hs
		214095 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		631638 KLH20_HUMAN (134-374): 1.12e-62: 212: 20.75		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		214409 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21
+	Hs
		214276 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		ZMY11_HUMAN (3-446): 1.03e-44: 171: 9.63
+	Dm
		1365592 RDX_DROME (1-374): 5.65e-111: 344: 79.41		Q9W1S2_DROME (26-226): 1.21e-39: 148: 24.02
+	Hs
		213994 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		998693 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Ce
		1089029 MEL26_CAEEL (17-354): 2.9e-71: 229: 31.12		Q17581_CAEEL (28-314): 2.32e-23: 107: 14.78
+	Hs
		245114 KLH20_HUMAN (134-374): 1.12e-62: 212: 20.75		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		600141 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		TAF1_HUMAN (23-303): 3.47e-17: 88.7: 13.52