HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SPD2A (Q5TCZ1)
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Gene: SH3PXD2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2, SH3_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 1133
+	Hs
		222014 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		NCK1_HUMAN (272-569): 6.56e-24: 107: 14.95
+	Hs
		51574 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		SPD2B_HUMAN (447-1132): 3.34e-18: 92.5: 13.64
+	Hs
		593897 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		NCK1_HUMAN (272-569): 6.56e-24: 107: 14.95
+	Hs
		221982 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		NCK2_HUMAN (372-603): 4.37e-15: 80.5: 12.20
+	Hs
		222084 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		ARHG6_HUMAN (791-1090): 3.78e-14: 79.4: 12.54
+	Hs
		51585 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		SPD2B_HUMAN (447-1132): 3.34e-18: 92.5: 13.64
+	Hs
		222080 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		ARHG7_HUMAN (974-1131): 2.45e-10: 67.1: 12.58
+	Hs
		594004 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		ARHG6_HUMAN (791-1090): 3.78e-14: 79.4: 12.54
+	Hs
		593993 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		ARHG7_HUMAN (974-1131): 2.45e-10: 67.1: 12.58
+	Hs
		1154182 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		ITSN1_HUMAN (810-1133): 1.11e-23: 110: 12.64
+	Hs
		1154087 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		ITSN1_HUMAN (810-1133): 1.11e-23: 110: 12.64
+	Hs
		1453434 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		ITSN2_HUMAN (156-292): 2.83e-14: 80.2: 13.87
+	Hs
		699767 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		ITSN1_HUMAN (810-1133): 1.11e-23: 110: 12.64
+	Hs
		593920 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		NCK1_HUMAN (272-569): 6.56e-24: 107: 14.95
+	Hs
		1384281 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		SH3K1_HUMAN (270-863): 7.39e-10: 65.2: 11.55
+	Hs
		1154148 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		SH3K1_HUMAN (270-863): 7.39e-10: 65.2: 11.55
+	Hs
		699824 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		SH3K1_HUMAN (270-863): 7.39e-10: 65.2: 11.55
+	Hs
		473458 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		SH3K1_HUMAN (270-863): 7.39e-10: 65.2: 11.55