Protein: SPD2B
SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)

Gene: SPD2B, SH3PXD2B
Organism: Homo sapiens
Interactions: 51
UniProt ID: A1X283

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001654 - eye development
GO:0002102 - podosome
GO:0005737 - cytoplasm
GO:0006801 - superoxide metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

51574

NCK2
Cytoplasmic protein NCK2

4

20

High-throughput

0.892

High

51585

NCK1
SH2/SH3 adapter protein NCK1

2

20

High-throughput

0.776

High

51593

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.776

High

51591

LIMK1
LIM domain kinase 1

1

20

High-throughput

0.691

High

51619

DBNL
Drebrin-like protein

1

19

High-throughput

0.691

High

51572

SPD2B
SH3 and PX domain-containing protein 2B

1

19

Small-scale

0.618

High

51579

P53
Cellular tumor antigen p53

1

2

High-throughput

0.618

High

51582

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

51607

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.618

High

51598

RASA2
Ras GTPase-activating protein 2

1

19

High-throughput

0.595

High

51610

ZN764
Zinc finger protein 764

2

2

High-throughput

0.574

High

51578

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

51586

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

51595

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.553

High

51577

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

51580

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

5

High-throughput

0.536

High

51603

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.513

High

51608

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.513

High

51599

TBCD9
TBC1 domain family member 9

1

2

High-throughput

0.489

High

51602

BCL9L
B-cell CLL/lymphoma 9-like protein

1

14

High-throughput

0.489

High

51612

T22D3
TSC22 domain family protein 3

1

1

High-throughput

0.489

High

51621

RT18C
Small ribosomal subunit protein bS18m

1

1

High-throughput

0.489

High

51576

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

51581

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.479

High

51583

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

51584

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

8

High-throughput

0.479

High

51588

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

51592

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

51596

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

51597

DCTN1
Dynactin subunit 1

1

13

High-throughput

0.479

High

51600

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

51604

BICD2
Protein bicaudal D homolog 2

1

17

High-throughput

0.479

High

51605

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

51614

WWTR1
WW domain-containing transcription regulator protein 1

1

12

High-throughput

0.479

High

51616

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

51617

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

51620

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.479

High

51589

CBX5
Chromobox protein homolog 5

1

3

High-throughput

0.470

High

51590

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

10

Small-scale

0.457

High

51573

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.445

High

51575

VENTX
Homeobox protein VENTX

1

6

High-throughput

0.445

High

51601

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

51609

BICD1
Protein bicaudal D homolog 1

1

14

High-throughput

0.437

High

51618

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

51606

ITFG2
KICSTOR complex protein ITFG2

2

0

High-throughput

0.328

High

51587

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.279

Low

51611

SORT
Sortilin

1

0

High-throughput

0.279

Low

51613

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

51615

GPBL1
Vasculin-like protein 1

1

0

High-throughput

0.279

Low

51594

TFAP4
Transcription factor AP-4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025