HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: WIPF2 (Q8TF74)
WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)
Gene: WIPF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	12213210, 26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 440
+	Hs
		222144 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		594056 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		WIPF2_HUMAN (1-440): 4.29e-32: 128: 100.00
+	Hs
		176246 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		594048 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		222101 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		TGO1_HUMAN (104-359): 3.97e-21: 98.8: 22.71
+	Hs
		65437 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		WIPF3_HUMAN (24-435): 4.63e-21: 97.2: 29.33
+	Hs
		65439 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		WIPF3_HUMAN (24-435): 4.63e-21: 97.2: 29.33
+	Hs
		215903 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		SYNJ1_HUMAN (103-438): 2.35e-18: 90.3: 17.19
+	Ce
		759769 Q95PW9_CAEEL (1-379): 2.06e-70: 227: 37.63		SC161_CAEEL (125-438): 4.95e-18: 89.1: 15.90
+	Hs
		1353774 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		WIPF2_HUMAN (1-440): 4.29e-32: 128: 100.00
+	Hs
		176277 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		176266 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		65447 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		WIPF3_HUMAN (24-435): 4.63e-21: 97.2: 29.33
+	Hs
		176248 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		463648 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		65445 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		WIPF3_HUMAN (24-435): 4.63e-21: 97.2: 29.33
+	Hs
		215925 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		SYNJ1_HUMAN (103-438): 2.35e-18: 90.3: 17.19
+	Hs
		319045 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		K0754_HUMAN (1-345): 1.42e-23: 106: 11.18
+	Hs
		699915 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		MYO16_HUMAN (3-288): 2.54e-10: 64.9: 14.00
+	Hs
		463316 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MUC1_HUMAN (142-437): 6.38e-11: 66.8: 11.15