HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: CSKI2 (Q8WXE0)
Caskin-2 (CASK-interacting protein 2)
Gene: CASKIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH3_2, Ank_2~SH3_1, SH3_1~SH3_2, Ank_2~SH3_9, SH3_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1202
+	Hs
		594061 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		CSKI2_HUMAN (1-1202): 3.56e-114: 386: 100.00
+	Hs
		222130 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		ANS1B_HUMAN (1-610): 3.52e-80: 290: 23.30
+	Hs
		463684 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		CSKI2_HUMAN (1-1202): 3.56e-114: 386: 100.00
+	Hs
		440160 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		CSKI2_HUMAN (1-1202): 3.56e-114: 386: 100.00
+	Mm
		1296766 ITSN1_MOUSE (6-102): 6.33e-16: 81.6: 22.68		ANS1B_MOUSE (1-610): 1.14e-78: 285: 23.60
+	Hs
		463835 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		KDIS_HUMAN (1-327): 2.32e-71: 264: 21.84
+	Hs
		593966 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		ANK2_HUMAN (196-320): 5.16e-16: 86.3: 25.40
+	Hs
		440239 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		KDIS_HUMAN (1-327): 2.32e-71: 264: 21.84
+	Mm
		109255 P85A_MOUSE (166-379): 9.21e-25: 107: 16.36		ANK3_MOUSE (3-439): 6.73e-65: 244: 16.80
+	Hs
		463836 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		ANR50_HUMAN (63-937): 1.86e-60: 229: 14.14
+	Hs
		699855 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		Q9H4D1_HUMAN (1-177): 5.62e-45: 177: 27.68
+	Hs
		319045 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		K0754_HUMAN (628-980): 6.37e-43: 174: 17.38
+	Ce
		234056 SRC2_CAEEL (1-194): 3.61e-19: 91: 17.73		Q93203_CAEEL (4-289): 7.5e-26: 117: 29.55
+	Hs
		1154121 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		MIB1_HUMAN (196-552): 3.08e-16: 86.5: 11.36
+	Ce
		711465 SEM5_CAEEL (204-364): 4.92e-16: 78.6: 30.68		Q93203_CAEEL (4-289): 7.5e-26: 117: 29.55
+	Hs
		699668 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		RIPK4_HUMAN (15-271): 2.23e-15: 83.6: 30.50
+	Hs
		463458 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		ANK2_HUMAN (196-320): 5.16e-16: 86.3: 25.40
+	Hs
		987550 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		ANK2_HUMAN (196-320): 5.16e-16: 86.3: 25.40
+	Hs
		463487 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		ANK3_HUMAN (56-264): 1.05e-09: 65.5: 28.23
+	Hs
		440051 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		ANK3_HUMAN (56-264): 1.05e-09: 65.5: 28.23