HitPredict

Interactor 1: SYUA (O55042)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: Snca

Interactor 2: SC6A3 (Q61327)
Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)
Gene: Slc6a3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	21990355, 22163275
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0009410 - response to xenobiotic stimulus GO:0042416 - dopamine biosynthetic process GO:0043679 - axon terminus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 140 Mm			1 619
+	Rn
		621437 SYUA_RAT (1-140): 6.7e-62: 188: 99.29		SC6A3_RAT (1-619): 0: 845: 99.19
+	Hs
		742227 SYUA_HUMAN (1-140): 7.95e-60: 183: 95.00		SC6A3_HUMAN (1-619): 0: 829: 93.39
+	Hs
		621433 SYUA_HUMAN (1-140): 7.95e-60: 183: 95.00		SC6A2_HUMAN (11-619): 0: 742: 66.34
+	Hs
		681218 SYUA_HUMAN (1-140): 7.95e-60: 183: 95.00		SC6A4_HUMAN (54-603): 0: 653: 50.45
+	Hs
		282768 SYUG_HUMAN (1-100): 1.29e-30: 108: 67.00		SC6A4_HUMAN (54-603): 0: 653: 50.45
+	Mm
		681266 SYUB_MOUSE (1-126): 5.97e-29: 104: 58.02		SC6A1_MOUSE (52-610): 0: 647: 45.63