HitPredict

Interactor 1: LDB2 (O43679)
LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)
Gene: LDB2

Interactor 2: LHX4 (Q969G2)
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Gene: LHX4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	18330356
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 373 Hs			1 390
+	Mm
		237320 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX4_MOUSE (1-390): 2.89e-108: 324: 98.97
+	Hs
		223951 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX3_HUMAN (1-390): 4.11e-88: 273: 60.25
+	Mm
		237334 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1A_MOUSE (2-347): 1.44e-64: 212: 27.37
+	Mm
		237322 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX5_MOUSE (29-388): 1.87e-63: 210: 32.93
+	Mm
		237324 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX1_MOUSE (29-389): 2.28e-61: 204: 32.13
+	Mm
		237317 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1B_MOUSE (10-347): 4.58e-58: 195: 28.27
+	Hs
		223924 LDB2_HUMAN (1-373): 0: 677: 100.00		RBTN1_HUMAN (14-158): 6.51e-56: 182: 38.00
+	Mm
		237329 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN1_MOUSE (14-158): 2.36e-55: 181: 38.00
+	Hs
		223927 LDB2_HUMAN (1-373): 0: 677: 100.00		ISL1_HUMAN (20-321): 4.69e-52: 178: 27.57
+	Mm
		237321 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL1_MOUSE (20-321): 4.69e-52: 178: 27.57
+	Hs
		223931 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX8_HUMAN (24-290): 9.31e-51: 175: 29.90
+	Mm
		237338 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX2_MOUSE (8-361): 1.7e-49: 173: 22.78
+	Hs
		223935 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO3_HUMAN (19-158): 4.35e-52: 172: 37.67
+	Mm
		237327 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO3_MOUSE (19-158): 4.35e-52: 172: 37.67
+	Mm
		237330 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL2_MOUSE (21-319): 2.65e-48: 169: 28.40
+	Mm
		237337 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX9_MOUSE (19-357): 1.01e-43: 158: 23.32
+	Hs
		253019 LDB1_HUMAN (8-373): 0: 610: 76.84		LMX1B_HUMAN (10-347): 2.23e-60: 202: 28.00
+	Hs
		223928 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO4_HUMAN (29-150): 2.23e-31: 118: 43.31
+	Mm
		237323 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO4_MOUSE (29-150): 2.23e-31: 118: 43.31
+	Hs
		682055 LDB1_HUMAN (8-373): 0: 610: 76.84		RBTN1_HUMAN (14-158): 6.51e-56: 182: 38.00