HitPredict

Interactor 1: LDB2 (O43679)
LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)
Gene: LDB2

Interactor 2: RBTN1 (P25800)
Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)
Gene: LMO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 373 Hs			1 156
+	Hs
		223927 LDB2_HUMAN (1-373): 0: 677: 100.00		ISL1_HUMAN (21-143): 1.27e-49: 164: 38.71
+	Mm
		237321 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL1_MOUSE (21-143): 1.27e-49: 164: 38.71
+	Mm
		237330 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL2_MOUSE (21-142): 1.37e-48: 161: 39.84
+	Hs
		223931 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX8_HUMAN (14-143): 5.22e-48: 160: 40.00
+	Hs
		223923 LDB2_HUMAN (1-373): 0: 677: 100.00		RBTN2_HUMAN (7-149): 3.38e-46: 149: 54.17
+	Mm
		237318 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN2_MOUSE (7-149): 2.93e-46: 149: 54.17
+	Mm
		237337 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX9_MOUSE (6-146): 1.04e-41: 144: 44.68
+	Mm
		237329 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN1_MOUSE (1-156): 1.94e-43: 142: 98.72
+	Hs
		223928 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO4_HUMAN (7-154): 2.54e-39: 132: 47.30
+	Mm
		237323 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO4_MOUSE (7-154): 2.54e-39: 132: 47.30
+	Hs
		223935 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO3_HUMAN (13-156): 5.12e-39: 130: 89.58
+	Mm
		237327 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO3_MOUSE (13-156): 5.12e-39: 130: 89.58
+	Hs
		223938 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX4_HUMAN (4-79): 1.02e-14: 71.9: 20.78
+	Mm
		237320 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX4_MOUSE (4-79): 9.81e-15: 71.9: 20.78
+	Hs
		223951 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX3_HUMAN (4-79): 4.45e-14: 70: 20.78
+	Mm
		237338 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX2_MOUSE (88-154): 3.65e-11: 61.9: 23.19
+	Mm
		237322 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX5_MOUSE (87-154): 3.46e-10: 58.8: 20.29
+	Mm
		237324 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX1_MOUSE (87-154): 4.29e-10: 58.8: 20.29
+	Mm
		237317 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1B_MOUSE (88-152): 1.44e-09: 57.3: 21.21
+	Mm
		237334 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1A_MOUSE (83-152): 2.01e-09: 56.5: 18.31