HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: CDC20 (Q12834)
Cell division cycle protein 20 homolog (p55CDC)
Gene: CDC20

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	24464857, 25833949, 25482201, 25306918, 26811472, 27114510, 28514442, 28410192, 33961781, 35913887, 21926987, 23643811, 23443559, 21407176
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007094 - mitotic spindle assembly checkpoint signaling GO:0033597 - mitotic checkpoint complex and 1 others more... GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 328 Hs			1 499
+	Hs
		224376 BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00		NLE1_HUMAN (167-499): 2.33e-87: 278: 19.27
+	Hs
		1450936 NLE1_HUMAN (86-320): 5.73e-48: 169: 13.03		NLE1_HUMAN (167-499): 2.33e-87: 278: 19.27
+	Sp
		1068482 TUP11_SCHPO (1-213): 1.77e-63: 213: 17.90		TUP11_SCHPO (251-497): 1.46e-57: 203: 16.92
+	Hs
		1007752 RAE1L_HUMAN (3-326): 4.38e-81: 252: 33.63		FBXW7_HUMAN (72-332): 1.54e-42: 162: 14.44
+	Hs
		224396 BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00		FZR1_HUMAN (315-495): 2.87e-24: 107: 19.02
+	Hs
		224258 BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	At
		1441695 BUB31_ARATH (1-324): 2.9e-85: 262: 52.89		CDC21_ARATH (378-499): 1.55e-15: 80.8: 17.32
+	At
		1441693 BUB31_ARATH (1-324): 2.9e-85: 262: 52.89		CDC22_ARATH (378-499): 1.79e-15: 80.4: 17.32
+	Sp
		1068486 TUP11_SCHPO (1-213): 1.77e-63: 213: 17.90		TUP12_SCHPO (336-497): 2.49e-29: 123: 21.02
+	Hs
		1380064 FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38		FBXW7_HUMAN (72-332): 1.54e-42: 162: 14.44
+	Sc
		684607 BUB3_YEAST (7-298): 2.54e-79: 246: 29.47		CDC20_YEAST (315-495): 5.15e-14: 76.6: 18.13
+	Hs
		984306 NLE1_HUMAN (86-320): 5.73e-48: 169: 13.03		GBB2_HUMAN (296-497): 1.4e-34: 134: 21.74
+	Hs
		845250 LIS1_HUMAN (1-165): 8.61e-43: 154: 15.71		LIS1_HUMAN (337-498): 3.83e-37: 143: 16.56
+	Mm
		988931 LIS1_MOUSE (1-165): 6.84e-43: 154: 15.71		LIS1_MOUSE (337-498): 2.98e-37: 143: 16.56
+	Dm
		1463899 WDS_DROME (1-166): 9.1e-38: 139: 14.61		WDS_DROME (342-498): 1.4e-42: 156: 20.25
+	Hs
		965276 NLE1_HUMAN (86-320): 5.73e-48: 169: 13.03		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		965141 FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		845264 LIS1_HUMAN (1-165): 8.61e-43: 154: 15.71		WDR5_HUMAN (55-254): 6.82e-17: 83.8: 9.18
+	Hs
		1334151 POC1B_HUMAN (134-327): 4.58e-40: 148: 13.73		POC1A_HUMAN (434-498): 7.24e-13: 72.3: 21.54
+	Hs
		845346 LIS1_HUMAN (1-165): 8.61e-43: 154: 15.71		KTNB1_HUMAN (321-470): 1.17e-09: 62.8: 30.26