Protein: B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

Gene: B2MG, B2M
Organism: Homo sapiens
Interactions: 120
UniProt ID: P61769

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001913 - T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002237 - response to molecule of bacterial origin
GO:0002481 - antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

901855

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

12

20

Small-scale

0.986

High

354403

HLAB
HLA class I histocompatibility antigen, B alpha chain

9

20

Small-scale

0.964

High

488183

HLAC
HLA class I histocompatibility antigen, C alpha chain

7

20

Small-scale

0.961

High

661085

CD1B
T-cell surface glycoprotein CD1b

5

20

Small-scale

0.926

High

901877

HFE
Hereditary hemochromatosis protein

4

18

Small-scale

0.900

High

879384

FCGRN
IgG receptor FcRn large subunit p51

4

20

Small-scale

0.899

High

901887

LIRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

4

20

Small-scale

0.873

High

901888

LIRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

4

20

Small-scale

0.873

High

570316

HLAG
HLA class I histocompatibility antigen, alpha chain G

4

19

Small-scale

0.867

High

382376

HLAA
HLA class I histocompatibility antigen, A alpha chain

3

20

Small-scale

0.853

High

673950

HLAF
HLA class I histocompatibility antigen, alpha chain F

3

20

Small-scale

0.847

High

550275

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

2

20

High-throughput

0.811

High

801666

RAGP1
Ran GTPase-activating protein 1

2

3

High-throughput

0.811

High

410555

CD1A
T-cell surface glycoprotein CD1a

2

20

Small-scale

0.778

High

550300

CD1D
Antigen-presenting glycoprotein CD1d

2

20

Small-scale

0.768

High

533137

HLAE
HLA class I histocompatibility antigen, alpha chain E

2

20

Small-scale

0.755

High

353510

IGKC
Immunoglobulin kappa constant

2

20

Small-scale

0.754

High

644557

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

2

20

Small-scale

0.754

High

901866

KLRD1
Natural killer cells antigen CD94

2

20

Small-scale

0.754

High

901878

Q5S3G3
HLA class I histocompatibility antigen A alpha chain

2

18

Small-scale

0.754

High

901891

HMR1
Major histocompatibility complex class I-related gene protein

1

18

Small-scale

0.716

High

601870

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

18

High-throughput

0.691

High

587496

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.665

High

901894

HMCN1
Hemicentin-1

1

1

High-throughput

0.665

High

304537

PRS23
Serine protease 23

1

0

High-throughput

0.663

High

69943

B1PKZ2
MHC class I antigen

1

20

Small-scale

0.647

High

186317

O19691
MHC class I lymphocyte antigen

1

20

Small-scale

0.647

High

364231

TFR1
Transferrin receptor protein 1

1

5

Small-scale

0.646

High

901872

PCOC1
Procollagen C-endopeptidase enhancer 1

2

8

Small-scale

0.644

High

131412

IMA4
Importin subunit alpha-4

2

4

High-throughput

0.628

High

134866

IMA3
Importin subunit alpha-3

2

4

High-throughput

0.628

High

236164

TPST1
Protein-tyrosine sulfotransferase 1

2

1

High-throughput

0.628

High

834704

RBP2
E3 SUMO-protein ligase RanBP2

2

3

High-throughput

0.628

High

901859

UBC9
SUMO-conjugating enzyme UBC9

2

1

High-throughput

0.628

High

901865

PUR1
Amidophosphoribosyltransferase

2

2

High-throughput

0.628

High

182265

TPSN
Tapasin

1

20

Small-scale

0.618

High

327879

NCTR2
Natural cytotoxicity triggering receptor 2

1

1

Small-scale

0.618

High

353332

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

4

Small-scale

0.618

High

644670

NKG2C
NKG2-C type II integral membrane protein

1

20

Small-scale

0.618

High

798138

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

20

Small-scale

0.618

High

798166

KI2L2
Killer cell immunoglobulin-like receptor 2DL2

1

20

Small-scale

0.618

High

798231

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

1

20

Small-scale

0.618

High

901869

IL27B
Interleukin-27 subunit beta

1

6

Small-scale

0.618

High

901870

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

1

20

Small-scale

0.618

High

901879

Q5SUL5
HLA class I histocompatibility antigen A alpha chain

1

18

Small-scale

0.618

High

901892

Q95J06
HLA class I histocompatibility antigen A alpha chain

1

18

Small-scale

0.618

High

901906

PD1L1
Programmed cell death 1 ligand 1

1

20

High-throughput

0.618

High

901871

IMB1
Importin subunit beta-1

2

0

High-throughput

0.602

High

901874

DLGP5
Disks large-associated protein 5

2

0

High-throughput

0.602

High

901883

CDCA2
Cell division cycle-associated protein 2

2

0

High-throughput

0.602

High

901862

TAP1
Antigen peptide transporter 1

2

16

Small-scale

0.601

High

517165

PCNA
Proliferating cell nuclear antigen

2

2

Small-scale

0.576

High

483421

RGPD2
RANBP2-like and GRIP domain-containing protein 2

2

3

High-throughput

0.574

High

901895

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

2

3

High-throughput

0.574

High

436902

ACM4
Muscarinic acetylcholine receptor M4

1

2

High-throughput

0.541

High

803474

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.541

High

528885

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.536

High

863921

CLH2
Clathrin heavy chain 2

1

2

High-throughput

0.536

High

901886

BRSK2
Serine/threonine-protein kinase BRSK2

1

1

High-throughput

0.536

High

901889

MK15
Mitogen-activated protein kinase 15

1

5

High-throughput

0.536

High

901901

DDX31
ATP-dependent DNA helicase DDX31

1

1

High-throughput

0.536

High

607802

USF1
Upstream stimulatory factor 1

1

5

Small-scale

0.534

High

901875

USF2
Upstream stimulatory factor 2

1

5

Small-scale

0.534

High

501025

IRF1
Interferon regulatory factor 1

1

5

Small-scale

0.515

High

536499

IRF2
Interferon regulatory factor 2

1

5

Small-scale

0.515

High

603049

OSBP1
Oxysterol-binding protein 1

1

1

High-throughput

0.515

High

901861

IRF8
Interferon regulatory factor 8

1

5

Small-scale

0.515

High

901864

TF65
Transcription factor p65

1

3

Small-scale

0.515

High

901873

IRF4
Interferon regulatory factor 4

1

5

Small-scale

0.515

High

901903

OTOF
Otoferlin

1

2

High-throughput

0.515

High

901882

MAP1S
Microtubule-associated protein 1S

1

0

High-throughput

0.513

High

901904

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

901857

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.508

High

901876

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.508

High

358999

CRYAB
Alpha-crystallin B chain

1

1

Small-scale

0.501

High

895600

CXCR4
C-X-C chemokine receptor type 4

1

4

Small-scale

0.501

High

434168

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

17

High-throughput

0.500

High

901912

MORC2
ATPase MORC2

1

0

High-throughput

0.493

High

578406

RCC1
Regulator of chromosome condensation

1

5

High-throughput

0.489

High

833703

CLK1
Dual specificity protein kinase CLK1

1

3

High-throughput

0.489

High

344473

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.480

High

50010

MEX3A
RNA-binding protein MEX3A

1

5

Small-scale

0.479

High

301718

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

352022

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

Small-scale

0.479

High

436238

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

516437

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

545302

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

555384

H2AX
Histone H2AX

1

2

Small-scale

0.479

High

569501

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

853224

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.479

High

892301

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

893861

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

900347

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

901856

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

901858

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

901860

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

901863

TAP2
Antigen peptide transporter 2

1

15

Small-scale

0.479

High

901880

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

1

Small-scale

0.479

High

901885

MEX3B
RNA-binding protein MEX3B

1

2

Small-scale

0.479

High

901897

CD244
Natural killer cell receptor 2B4

1

10

Small-scale

0.479

High

901898

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.479

High

901900

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

901902

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

901905

T106B
Transmembrane protein 106B

1

18

High-throughput

0.479

High

901907

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

901910

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.479

High

901911

TLN1
Talin-1

1

5

High-throughput

0.479

High

122611

MEN1
Menin

1

0

High-throughput

0.458

High

901908

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

901881

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

7

Small-scale

0.437

High

901899

P63
Tumor protein 63

1

1

Small-scale

0.417

High

901867

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.407

High

901868

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.407

High

147068

NEMP1
Nuclear envelope integral membrane protein 1

2

0

High-throughput

0.328

High

901896

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.279

Low

901909

PYGO1
Pygopus homolog 1

1

0

High-throughput

0.268

Low

901890

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

901884

LIN54
Protein lin-54 homolog

1

0

Small-scale

0.232

Low

901893

LIN37
Protein lin-37 homolog

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024