HitPredict

Interactor 1: SIGL6 (O43699)
Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
Gene: SIGLEC6

Interactor 2: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 453 Hs			1 189
+	Hs
		374079 CADM4_HUMAN (35-401): 8.86e-64: 212: 20.15		RASN_HUMAN (1-188): 4.47e-88: 257: 85.64
+	Hs
		373750 NCAM1_HUMAN (2-445): 1.18e-37: 148: 13.28		RASN_HUMAN (1-188): 4.47e-88: 257: 85.64
+	Hs
		375136 NCAM1_HUMAN (2-445): 1.18e-37: 148: 13.28		RASK_HUMAN (1-188): 1.61e-84: 249: 86.24
+	Hs
		373908 PTK7_HUMAN (27-445): 1.18e-30: 127: 13.77		RASN_HUMAN (1-188): 4.47e-88: 257: 85.64
+	Hs
		375481 PTK7_HUMAN (27-445): 1.18e-30: 127: 13.77		RASK_HUMAN (1-188): 1.61e-84: 249: 86.24
+	Hs
		374372 NCAM1_HUMAN (2-445): 1.18e-37: 148: 13.28		RASH_HUMAN (16-189): 6.27e-73: 219: 100.00
+	Hs
		373768 MAG_HUMAN (7-451): 3.52e-24: 107: 13.76		RASN_HUMAN (1-188): 4.47e-88: 257: 85.64
+	Hs
		373936 NECT1_HUMAN (7-360): 9.31e-22: 99.8: 20.64		RASN_HUMAN (1-188): 4.47e-88: 257: 85.64
+	Hs
		375536 NECT1_HUMAN (7-360): 9.31e-22: 99.8: 20.64		RASK_HUMAN (1-188): 1.61e-84: 249: 86.24
+	Hs
		374318 ROBO1_HUMAN (242-442): 1.48e-18: 90.9: 14.22		RASN_HUMAN (1-188): 4.47e-88: 257: 85.64
+	Hs
		374565 PTK7_HUMAN (27-445): 1.18e-30: 127: 13.77		RASH_HUMAN (16-189): 6.27e-73: 219: 100.00
+	Hs
		376163 ROBO1_HUMAN (242-442): 1.48e-18: 90.9: 14.22		RASK_HUMAN (1-188): 1.61e-84: 249: 86.24
+	Hs
		375909 CADM1_HUMAN (37-337): 1.17e-18: 89.8: 18.18		RASK_HUMAN (1-188): 1.61e-84: 249: 86.24
+	Hs
		375974 ROBO2_HUMAN (240-448): 3.45e-18: 89.7: 15.42		RASK_HUMAN (1-188): 1.61e-84: 249: 86.24
+	Hs
		374609 NECT1_HUMAN (7-360): 9.31e-22: 99.8: 20.64		RASH_HUMAN (16-189): 6.27e-73: 219: 100.00
+	Hs
		976711 ROBO1_HUMAN (242-442): 1.48e-18: 90.9: 14.22		RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90
+	Hs
		375784 TITIN_HUMAN (61-445): 4.13e-09: 61.2: 10.45		RASK_HUMAN (1-188): 1.61e-84: 249: 86.24
+	Hs
		375059 ROBO1_HUMAN (242-442): 1.48e-18: 90.9: 14.22		RASH_HUMAN (16-189): 6.27e-73: 219: 100.00
+	Hs
		374901 CADM1_HUMAN (37-337): 1.17e-18: 89.8: 18.18		RASH_HUMAN (16-189): 6.27e-73: 219: 100.00
+	Hs
		619664 VCAM1_HUMAN (105-365): 6.9e-20: 94.4: 19.42		RAP1B_HUMAN (1-165): 2.19e-63: 195: 57.49