HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: CADM1 (Q9BY67)
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Gene: CADM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 442
+	Hs
		374901 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		CADM1_HUMAN (1-442): 6.86e-84: 265: 100.00
+	Hs
		374217 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		NECT3_HUMAN (52-439): 4.92e-73: 240: 23.25
+	Hs
		374079 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		CADM4_HUMAN (45-442): 2.65e-74: 239: 35.18
+	Hs
		375987 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		NECT3_HUMAN (52-439): 4.92e-73: 240: 23.25
+	Hs
		374609 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		NECT1_HUMAN (28-410): 5.16e-64: 216: 23.42
+	Hs
		373936 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		NECT1_HUMAN (28-410): 5.16e-64: 216: 23.42
+	Hs
		375536 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		NECT1_HUMAN (28-410): 5.16e-64: 216: 23.42
+	Hs
		375974 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		ROBO2_HUMAN (138-438): 5.1e-51: 187: 16.08
+	Hs
		375059 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		ROBO1_HUMAN (18-378): 8.48e-33: 133: 14.61
+	Hs
		374318 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		ROBO1_HUMAN (18-378): 8.48e-33: 133: 14.61
+	Hs
		1145208 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		ROBO1_HUMAN (18-378): 8.48e-33: 133: 14.61
+	Hs
		374855 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		374138 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		1145058 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		374822 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		NECT2_HUMAN (109-334): 8.36e-15: 78.2: 27.07
+	Hs
		374107 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		NECT2_HUMAN (109-334): 8.36e-15: 78.2: 27.07
+	Hs
		1145046 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		NECT2_HUMAN (109-334): 8.36e-15: 78.2: 27.07
+	Hs
		375842 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		KIRR1_HUMAN (19-245): 2.92e-18: 89.6: 14.59
+	Hs
		375796 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		NECT2_HUMAN (109-334): 8.36e-15: 78.2: 27.07
+	Hs
		375784 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		TITIN_HUMAN (122-441): 6.65e-09: 60.7: 12.97