HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1070
+	Hs
		375974 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		ROBO2_HUMAN (1-810): 9.04e-106: 363: 15.91
+	Hs
		375481 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		PTK7_HUMAN (2-329): 4.58e-53: 204: 19.94
+	Hs
		1145171 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		ALK_HUMAN (695-1067): 1.22e-52: 204: 32.90
+	Hs
		411698 RB11A_HUMAN (4-184): 8.81e-75: 225: 33.88		NTRK1_HUMAN (555-1061): 3.11e-57: 214: 30.31
+	Hs
		374565 RASH_HUMAN (16-188): 6.69e-79: 234: 84.39		PTK7_HUMAN (2-329): 4.58e-53: 204: 19.94
+	Hs
		411703 RAP1A_HUMAN (1-165): 1.22e-60: 188: 56.29		NTRK1_HUMAN (555-1061): 3.11e-57: 214: 30.31
+	Hs
		411257 RALA_HUMAN (4-169): 7.18e-59: 184: 53.89		NTRK1_HUMAN (555-1061): 3.11e-57: 214: 30.31
+	Hs
		541421 RAB8A_HUMAN (4-185): 1.75e-84: 249: 36.02		FGFR1_HUMAN (2-231): 1.1e-34: 145: 12.77
+	Hs
		541423 RAB1A_HUMAN (4-187): 2.9e-77: 231: 33.33		FGFR1_HUMAN (2-231): 1.1e-34: 145: 12.77
+	Hs
		541422 RAB14_HUMAN (4-185): 1.88e-73: 222: 29.35		FGFR1_HUMAN (2-231): 1.1e-34: 145: 12.77
+	Hs
		541510 RB11B_HUMAN (4-184): 1.56e-73: 222: 32.79		FGFR1_HUMAN (2-231): 1.1e-34: 145: 12.77
+	Hs
		1055093 RAB1B_HUMAN (4-187): 2.79e-76: 228: 33.51		TYRO3_HUMAN (226-606): 1.4e-26: 119: 13.14
+	Hs
		541424 RAP1A_HUMAN (1-165): 1.22e-60: 188: 56.29		FGFR1_HUMAN (2-231): 1.1e-34: 145: 12.77
+	Hs
		374625 RASH_HUMAN (16-188): 6.69e-79: 234: 84.39		NTRK3_HUMAN (40-228): 3.85e-16: 85.5: 19.10
+	Hs
		375784 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		TITIN_HUMAN (599-828): 3.2e-10: 67: 15.25
+	Rn
		628680 RASH_RAT (16-188): 6.69e-79: 234: 84.39		NTRK1_RAT (35-241): 4.57e-10: 65.9: 19.28
+	Hs
		976456 RB11A_HUMAN (4-184): 8.81e-75: 225: 33.88		TITIN_HUMAN (599-828): 3.2e-10: 67: 15.25
+	Hs
		957983 RAB14_HUMAN (4-185): 1.88e-73: 222: 29.35		TITIN_HUMAN (599-828): 3.2e-10: 67: 15.25