HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1454 Hs			1 217
+	Hs
		225343 MED14_HUMAN (1-1454): 0: 1560: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		225326 MED14_HUMAN (1-1454): 0: 1560: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		225333 MED14_HUMAN (1-1454): 0: 1560: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		195974 PLXB1_HUMAN (986-1225): 9.69e-23: 108: 18.39		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924632 TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		554292 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924760 PRG4_HUMAN (985-1206): 9.56e-09: 62.5: 16.14		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411844 TB182_HUMAN (945-1135): 6.75e-20: 99.2: 18.33		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411582 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		782795 TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		297808 K0754_HUMAN (1071-1454): 6.75e-24: 112: 11.54		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		337335 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		433989 TB182_HUMAN (945-1135): 6.75e-20: 99.2: 18.33		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		101430 F8VPR5_MOUSE (836-1217): 4.53e-09: 63.8: 7.75		CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57
+	Hs
		442866 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433930 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		523092 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433560 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522749 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		101424 F8VPR5_MOUSE (836-1217): 4.53e-09: 63.8: 7.75		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47