Protein: ERD21
ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23)

Gene: ERD21, KDELR1
Organism: Homo sapiens
Interactions: 107
UniProt ID: P24390

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005046 - KDEL sequence binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

665015

UBQL4
Ubiquilin-4

2

1

High-throughput

0.628

High

664994

NPL4
Nuclear protein localization protein 4 homolog

2

0

High-throughput

0.602

High

665020

RN115
E3 ubiquitin-protein ligase RNF115

2

0

High-throughput

0.602

High

664960

COPB
Coatomer subunit beta

2

1

Small-scale

0.595

High

664965

RAC1
Ras-related C3 botulinum toxin substrate 1

2

1

High-throughput

0.571

High

664992

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

0

Small-scale

0.569

High

240779

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

664976

DLG2
Disks large homolog 2

2

1

High-throughput

0.553

High

665000

DLG3
Disks large homolog 3

2

1

High-throughput

0.553

High

184382

SURF4
Surfeit locus protein 4

1

2

High-throughput

0.536

High

538520

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.536

High

563214

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

664983

FA2H
Fatty acid 2-hydroxylase

1

1

High-throughput

0.536

High

664996

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

665002

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

5

High-throughput

0.536

High

665016

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

3

High-throughput

0.536

High

665019

UBQL1
Ubiquilin-1

1

2

High-throughput

0.536

High

395505

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

664971

SERC3
Serine incorporator 3

1

1

High-throughput

0.515

High

336524

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

664997

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.513

High

665007

SEC62
Translocation protein SEC62

1

0

High-throughput

0.513

High

665008

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.513

High

664967

ARF1
ADP-ribosylation factor 1

1

3

Small-scale

0.501

High

664959

CCR9
C-C chemokine receptor type 9

1

5

High-throughput

0.494

High

664963

PAR2
Proteinase-activated receptor 2

1

8

High-throughput

0.494

High

665013

GPR35
G-protein coupled receptor 35

1

5

High-throughput

0.494

High

127876

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

2

High-throughput

0.489

High

128146

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

High-throughput

0.489

High

141818

ACKR2
Atypical chemokine receptor 2

1

5

High-throughput

0.489

High

165905

FFAR1
Free fatty acid receptor 1

1

10

High-throughput

0.489

High

320430

TM63A
Mechanosensitive cation channel TMEM63A

1

1

High-throughput

0.489

High

351874

S1PR4
Sphingosine 1-phosphate receptor 4

1

7

High-throughput

0.489

High

618371

TSN8
Tetraspanin-8

1

1

High-throughput

0.489

High

664943

EDNRA
Endothelin-1 receptor

1

3

High-throughput

0.489

High

664946

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

4

High-throughput

0.489

High

664948

APJ
Apelin receptor

1

3

High-throughput

0.489

High

664950

P2RY2
P2Y purinoceptor 2

1

8

High-throughput

0.489

High

664951

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

4

High-throughput

0.489

High

664952

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.489

High

664973

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.489

High

664977

RABL3
Rab-like protein 3

1

4

High-throughput

0.489

High

664986

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

8

High-throughput

0.489

High

665004

OPALI
Opalin

1

2

High-throughput

0.489

High

665017

GINM1
Glycoprotein integral membrane protein 1

1

1

High-throughput

0.489

High

665022

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

217844

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

225356

ERD23
ER lumen protein-retaining receptor 3

1

4

High-throughput

0.479

High

664942

ERD21
ER lumen protein-retaining receptor 1

1

4

Small-scale

0.479

High

664947

ERD22
ER lumen protein-retaining receptor 2

1

4

High-throughput

0.479

High

664958

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.479

High

664974

SC23A
Protein transport protein Sec23A

1

1

Small-scale

0.479

High

665014

NEK6
Serine/threonine-protein kinase Nek6

1

2

High-throughput

0.470

High

605558

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

Small-scale

0.457

High

664945

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.445

High

486965

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.437

High

664953

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

High-throughput

0.437

High

664955

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.437

High

664956

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.437

High

664966

H31
Histone H3.1

1

1

High-throughput

0.437

High

664968

H33
Histone H3.3

1

1

High-throughput

0.437

High

664999

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

665009

TRI55
Tripartite motif-containing protein 55

1

1

High-throughput

0.437

High

665010

RHOJ
Rho-related GTP-binding protein RhoJ

1

1

High-throughput

0.437

High

664978

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

665005

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.426

High

664975

SC23B
Protein transport protein Sec23B

1

1

Small-scale

0.408

High

248838

GSDME
Gasdermin-E

1

1

High-throughput

0.407

High

664954

GPR12
G-protein coupled receptor 12

1

6

High-throughput

0.407

High

664987

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

664995

S7A14
Solute carrier family 7 member 14

1

2

High-throughput

0.407

High

664998

LPAR1
Lysophosphatidic acid receptor 1

1

7

High-throughput

0.407

High

156117

TRAD1
TRAF-type zinc finger domain-containing protein 1

2

0

High-throughput

0.328

High

664969

UBE3A
Ubiquitin-protein ligase E3A

2

0

High-throughput

0.328

High

664984

VPS36
Vacuolar protein-sorting-associated protein 36

2

0

High-throughput

0.328

High

664985

TAXB1
Tax1-binding protein 1

2

0

High-throughput

0.328

High

664990

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

2

0

High-throughput

0.328

High

665006

UBL7
Ubiquitin-like protein 7

2

0

High-throughput

0.328

High

665021

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

2

0

High-throughput

0.328

High

300301

KRT34
Keratin, type I cuticular Ha4

2

0

High-throughput

0.316

High

530999

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.298

High

664944

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.298

High

664957

DNLI4
DNA ligase 4

1

0

High-throughput

0.288

High

664962

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.279

Low

664972

KCNC3
Voltage-gated potassium channel KCNC3

1

0

High-throughput

0.279

Low

664988

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

664989

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

664991

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.279

Low

664993

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.279

Low

665001

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.279

Low

665003

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

664982

5MP2
eIF5-mimic protein 2

1

0

High-throughput

0.269

Low

665018

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.269

Low

125242

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

293213

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

519049

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

664949

COIL
Coilin

1

0

High-throughput

0.249

Low

664961

ATX3
Ataxin-3

1

0

High-throughput

0.249

Low

664964

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

664970

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

664979

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

664981

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

665011

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.249

Low

665012

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

529102

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

664980

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025