HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	16862145
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016235 - aggresome GO:0017124 - SH3 domain binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 896
+	Mm
		788009 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54
+	Hs
		475452 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00
+	Hs
		227694 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FKB15_HUMAN (76-873): 1.31e-37: 154: 11.35
+	Hs
		226042 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIPA2_HUMAN (210-884): 2.13e-31: 134: 11.53
+	Hs
		228697 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72
+	Hs
		228925 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EHD3_HUMAN (12-102): 5.49e-15: 80.8: 28.57
+	Hs
		228926 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EHD2_HUMAN (19-102): 1.88e-12: 72.7: 27.38
+	Hs
		228663 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EHD4_HUMAN (213-318): 5.77e-11: 68.2: 38.68
+	Hs
		476483 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40
+	Sc
		477209 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		EDE1_YEAST (3-327): 3e-15: 82.9: 24.01
+	Hs
		475816 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61
+	Sc
		477280 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		END3_YEAST (15-378): 4.53e-13: 73.6: 17.73
+	Hs
		475882 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKB15_HUMAN (76-873): 1.31e-37: 154: 11.35
+	Hs
		476502 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98