Protein: SET1A
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)

Gene: SET1A, SETD1A
Organism: Homo sapiens
Interactions: 155
UniProt ID: O15047

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175891

RBBP5
Retinoblastoma-binding protein 5

18

20

Small-scale

0.986

High

175937

CXXC1
CXXC-type zinc finger protein 1

18

19

Small-scale

0.986

High

175941

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

16

20

Small-scale

0.985

High

175897

WDR82
WD repeat-containing protein 82

10

20

Small-scale

0.975

High

175872

H31
Histone H3.1

3

20

Small-scale

0.845

High

175884

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

1

High-throughput

0.811

High

175868

WDR5
WD repeat-containing protein 5

19

20

Small-scale

0.765

High

161371

KMT2D
Histone-lysine N-methyltransferase 2D

2

20

High-throughput

0.754

High

175824

H2A1B
Histone H2A type 1-B/E

2

15

High-throughput

0.754

High

175951

SET1B
Histone-lysine N-methyltransferase SETD1B

2

17

Small-scale

0.754

High

175924

DPY30
Protein dpy-30 homolog

5

7

Small-scale

0.709

High

175860

HCFC1
Host cell factor 1

5

20

Small-scale

0.709

High

175826

H2A1
Histone H2A type 1

1

15

High-throughput

0.691

High

175950

PHF8
Histone lysine demethylase PHF8

1

16

Small-scale

0.691

High

175810

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

4

12

Small-scale

0.683

High

175823

P53
Cellular tumor antigen p53

3

4

Small-scale

0.678

High

175864

ANM2
Protein arginine N-methyltransferase 2

3

5

High-throughput

0.667

High

175945

NUP50
Nuclear pore complex protein Nup50

3

5

High-throughput

0.667

High

175957

HCFC2
Host cell factor 2

3

20

High-throughput

0.667

High

175933

E41L5
Band 4.1-like protein 5

3

10

High-throughput

0.662

High

175911

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

3

20

High-throughput

0.656

High

175899

H32
Histone H3.2

1

20

Small-scale

0.647

High

175822

MYC
Myc proto-oncogene protein

3

12

High-throughput

0.640

High

139434

PESC
Pescadillo homolog

2

1

High-throughput

0.628

High

175813

E41L2
Band 4.1-like protein 2

2

11

High-throughput

0.628

High

175815

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

175835

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.618

High

175839

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

10

Small-scale

0.618

High

175849

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

175861

NEK2
Serine/threonine-protein kinase Nek2

1

2

High-throughput

0.618

High

175869

H4
Histone H4

1

9

High-throughput

0.618

High

175870

TRA2B
Transformer-2 protein homolog beta

1

15

High-throughput

0.618

High

175871

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.618

High

175876

KMT2A
Histone-lysine N-methyltransferase 2A

1

19

High-throughput

0.618

High

175877

RBBP4
Histone-binding protein RBBP4

1

20

High-throughput

0.618

High

175883

TIF1B
Transcription intermediary factor 1-beta

1

18

High-throughput

0.618

High

175886

NFYC
Nuclear transcription factor Y subunit gamma

1

2

High-throughput

0.618

High

175888

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

175890

SUZ12
Polycomb protein SUZ12

1

11

High-throughput

0.618

High

175893

EZH2
Histone-lysine N-methyltransferase EZH2

1

19

High-throughput

0.618

High

175910

KMT2C
Histone-lysine N-methyltransferase 2C

1

18

High-throughput

0.618

High

175912

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

175922

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

Small-scale

0.618

High

175948

KMT2B
Histone-lysine N-methyltransferase 2B

1

18

High-throughput

0.618

High

175956

MRCKB
Serine/threonine-protein kinase MRCK beta

1

9

High-throughput

0.618

High

175917

EDA
Ectodysplasin-A

3

1

High-throughput

0.609

High

175896

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

175878

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.586

High

128621

MEN1
Menin

2

7

High-throughput

0.584

High

175828

MYB
Transcriptional activator Myb

2

7

High-throughput

0.584

High

175837

USF1
Upstream stimulatory factor 1

2

10

Small-scale

0.584

High

175880

TP53B
TP53-binding protein 1

2

7

High-throughput

0.584

High

175892

ELF2
ETS-related transcription factor Elf-2

2

20

High-throughput

0.584

High

175954

E41L3
Band 4.1-like protein 3

2

11

High-throughput

0.574

High

175916

CBP
CREB-binding protein

1

20

Small-scale

0.561

High

175927

E41L1
Band 4.1-like protein 1

2

10

High-throughput

0.549

High

175829

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

2

High-throughput

0.536

High

175856

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

175862

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.536

High

175874

ZXDB
Zinc finger X-linked protein ZXDB

1

2

High-throughput

0.536

High

175882

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

175905

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

2

High-throughput

0.536

High

175909

ZN784
Zinc finger protein 784

1

4

High-throughput

0.536

High

175913

ARRD2
Arrestin domain-containing protein 2

1

1

High-throughput

0.536

High

175926

E41LB
Band 4.1-like protein 4B

1

10

High-throughput

0.536

High

175943

DAXX
Death domain-associated protein 6

1

3

High-throughput

0.536

High

175918

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.513

High

175940

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

175830

INSRR
Insulin receptor-related protein

1

4

High-throughput

0.489

High

175906

FGRL1
Fibroblast growth factor receptor-like 1

1

4

High-throughput

0.489

High

175908

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

71418

P20L1
PHD finger protein 20-like protein 1

1

11

High-throughput

0.479

High

163661

TCRG1
Transcription elongation regulator 1

1

5

Small-scale

0.479

High

175811

KDM6A
Lysine-specific demethylase 6A

1

20

High-throughput

0.479

High

175812

TPD54
Tumor protein D54

1

2

High-throughput

0.479

High

175814

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

17

High-throughput

0.479

High

175817

CCNK
Cyclin-K

1

4

Small-scale

0.479

High

175818

MTA2
Metastasis-associated protein MTA2

1

11

High-throughput

0.479

High

175819

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

175825

PARP1
Poly [ADP-ribose] polymerase 1

1

13

High-throughput

0.479

High

175831

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

175832

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

Small-scale

0.479

High

175834

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

175838

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.479

High

175840

TYY1
Transcriptional repressor protein YY1

1

9

High-throughput

0.479

High

175841

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

175842

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

20

Small-scale

0.479

High

175843

RBL1
Retinoblastoma-like protein 1

1

9

Small-scale

0.479

High

175845

DNJA1
DnaJ homolog subfamily A member 1

1

7

Small-scale

0.479

High

175846

1433S
14-3-3 protein sigma

1

19

Small-scale

0.479

High

175848

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

175850

MCM7
DNA replication licensing factor MCM7

1

8

Small-scale

0.479

High

175851

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

175852

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.479

High

175853

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

175854

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

175855

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

175857

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

175858

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

15

High-throughput

0.479

High

175859

CTCF
Transcriptional repressor CTCF

1

1

High-throughput

0.479

High

175863

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

175865

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

175866

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.479

High

175867

RL37A
Large ribosomal subunit protein eL43

1

3

High-throughput

0.479

High

175873

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.479

High

175875

E2F1
Transcription factor E2F1

1

10

Small-scale

0.479

High

175879

AHNK
Neuroblast differentiation-associated protein AHNAK

1

11

High-throughput

0.479

High

175881

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

175885

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.479

High

175887

FHL2
Four and a half LIM domains protein 2

1

3

High-throughput

0.479

High

175889

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

175898

PAXI1
PAX-interacting protein 1

1

20

High-throughput

0.479

High

175900

PHF5A
PHD finger-like domain-containing protein 5A

1

1

High-throughput

0.479

High

175901

KANL1
KAT8 regulatory NSL complex subunit 1

1

3

High-throughput

0.479

High

175902

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

175904

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

175907

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.479

High

175914

DCAF4
DDB1- and CUL4-associated factor 4

1

2

High-throughput

0.479

High

175915

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

175919

MCRS1
Microspherule protein 1

1

4

High-throughput

0.479

High

175920

FEV
Protein FEV

1

20

High-throughput

0.479

High

175921

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

175923

PHF20
PHD finger protein 20

1

20

High-throughput

0.479

High

175928

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

175929

KAT8
Histone acetyltransferase KAT8

1

6

High-throughput

0.479

High

175930

CSR2B
Cysteine-rich protein 2-binding protein

1

20

High-throughput

0.479

High

175931

KANL2
KAT8 regulatory NSL complex subunit 2

1

3

High-throughput

0.479

High

175932

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

20

High-throughput

0.479

High

175934

MBIP1
MAP3K12-binding inhibitory protein 1

1

3

High-throughput

0.479

High

175936

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

175938

KANL3
KAT8 regulatory NSL complex subunit 3

1

4

High-throughput

0.479

High

175939

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.479

High

175942

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.479

High

175944

APC7
Anaphase-promoting complex subunit 7

1

10

High-throughput

0.479

High

175946

ZN608
Zinc finger protein 608

1

10

High-throughput

0.479

High

175947

YETS2
YEATS domain-containing protein 2

1

20

High-throughput

0.479

High

175949

PRP19
Pre-mRNA-processing factor 19

1

20

Small-scale

0.479

High

175952

SMC3
Structural maintenance of chromosomes protein 3

1

6

Small-scale

0.479

High

175953

RUVB2
RuvB-like 2

1

6

High-throughput

0.479

High

175955

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

158534

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

0

High-throughput

0.458

High

175816

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.458

High

175844

MPIP1
M-phase inducer phosphatase 1

1

0

Small-scale

0.458

High

175894

UVSSA
UV-stimulated scaffold protein A

1

0

Small-scale

0.458

High

175935

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

49951

RHG10
Rho GTPase-activating protein 10

1

3

High-throughput

0.437

High

175820

PCNT
Pericentrin

1

19

High-throughput

0.437

High

175847

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

2

High-throughput

0.437

High

175827

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

175836

MK
Midkine

2

0

High-throughput

0.328

High

175821

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

175903

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

175925

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.279

Low

175833

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.251

Low

175895

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025