HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 900
+	Hs
		226494 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NFKB1_HUMAN (6-881): 0: 586: 41.27
+	Hs
		474996 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		NFKB2_HUMAN (1-900): 0: 713: 100.00
+	Hs
		475636 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NFKB2_HUMAN (1-900): 0: 713: 100.00
+	Hs
		227235 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		REL_HUMAN (33-456): 2.67e-112: 359: 33.88
+	Hs
		227227 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TF65_HUMAN (24-354): 9.91e-113: 358: 40.96
+	Hs
		978884 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		TF65_HUMAN (24-354): 9.91e-113: 358: 40.96
+	Hs
		312581 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		REL_HUMAN (33-456): 2.67e-112: 359: 33.88
+	Hs
		227310 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANK3_HUMAN (640-880): 4.84e-38: 157: 14.18
+	Hs
		475001 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		TF65_HUMAN (24-354): 9.91e-113: 358: 40.96
+	Hs
		227985 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANKH1_HUMAN (624-876): 1.11e-32: 139: 20.60
+	Hs
		121551 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IKBE_HUMAN (472-704): 4.58e-25: 112: 38.98
+	Mm
		222606 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		IKBE_MOUSE (477-701): 1.51e-29: 123: 39.39
+	Hs
		474999 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RELB_HUMAN (27-356): 5.22e-89: 296: 39.34
+	Hs
		475649 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TF65_HUMAN (24-354): 9.91e-113: 358: 40.96
+	Hs
		476162 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MIB2_HUMAN (404-803): 4.48e-74: 263: 21.59
+	Mm
		1141375 ARI2_MOUSE (222-464): 1.03e-64: 218: 20.82		IKBB_MOUSE (486-704): 2.54e-17: 86.7: 31.27
+	Hs
		475034 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		IKBB_HUMAN (486-692): 3.79e-20: 95.1: 33.74
+	Hs
		476024 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ANKH1_HUMAN (624-876): 1.11e-32: 139: 20.60
+	Hs
		476011 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MIB1_HUMAN (564-805): 4.43e-30: 130: 20.54
+	Hs
		475361 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IKBA_HUMAN (486-677): 9.26e-26: 110: 39.38