HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042981 - regulation of apoptotic process GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1235
+	Hs
		148181 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		228811 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNRK_HUMAN (27-738): 6.02e-125: 405: 16.78
+	Hs
		226534 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KAPCB_HUMAN (2-343): 6.64e-126: 393: 23.86
+	Hs
		227381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2D_HUMAN (31-423): 9.26e-116: 371: 27.25
+	Hs
		229082 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2A_HUMAN (31-423): 1.9e-113: 364: 25.25
+	Hs
		227338 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAK2_HUMAN (7-305): 1.42e-110: 358: 36.79
+	Hs
		227519 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A2_HUMAN (22-353): 4.19e-97: 328: 22.65
+	Hs
		226918 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A3_HUMAN (22-342): 5.85e-95: 323: 22.49
+	Hs
		229162 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		M4K5_HUMAN (29-292): 6.48e-62: 230: 44.74
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (12-424): 3.38e-132: 415: 20.19
+	At
		1091633 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPK5_ARATH (7-478): 3.54e-129: 409: 18.96
+	At
		1092417 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKQ_ARATH (25-478): 8.62e-130: 408: 18.83
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (33-394): 2.23e-127: 403: 20.82
+	Hs
		475723 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KCC2D_HUMAN (31-423): 9.26e-116: 371: 27.25
+	Hs
		226028 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ROCK2_HUMAN (590-1232): 1.74e-15: 84.3: 10.38
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (30-307): 9.15e-63: 224: 43.73