Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2
Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.79 | 1.00 | 0.893 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25402006, 24658140, 17126326, unassigned2173 |
| Identification Methods | two hybrid, protein complementation assay, anti tag coimmunoprecipitation, ubiquitin reconstruction, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0004888 - transmembrane signaling receptor activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0009986 - cell surface and 4 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
