Protein: PKN3
Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)

Gene: PKN3
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q6P5Z2

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1243072

RHG26
Rho GTPase-activating protein 26

4

9

Small-scale

0.905

High

962172

RHOA
Transforming protein RhoA

4

20

High-throughput

0.892

High

788942

TGFR2
TGF-beta receptor type-2

3

4

High-throughput

0.861

High

1243013

SKAP1
Src kinase-associated phosphoprotein 1

3

20

High-throughput

0.861

High

49969

RHG10
Rho GTPase-activating protein 10

2

10

Small-scale

0.838

High

69793

ZN785
Zinc finger protein 785

2

1

High-throughput

0.811

High

845438

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

4

High-throughput

0.770

High

1243074

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

2

High-throughput

0.770

High

406899

MAS
Proto-oncogene Mas

2

1

High-throughput

0.726

High

1243008

DEFI8
Differentially expressed in FDCP 8 homolog

2

16

High-throughput

0.726

High

1243026

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.726

High

1103763

PLD1
Phospholipase D1

1

5

Small-scale

0.724

High

211345

RFOX2
RNA binding protein fox-1 homolog 2

1

6

High-throughput

0.691

High

461602

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

468505

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

718135

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

High-throughput

0.691

High

868325

V1BR
Vasopressin V1b receptor

1

4

High-throughput

0.691

High

938743

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

5

High-throughput

0.691

High

1105971

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

10

High-throughput

0.691

High

1110263

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

10

High-throughput

0.691

High

1110361

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

9

High-throughput

0.691

High

1110472

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

7

High-throughput

0.691

High

1116817

AVR2B
Activin receptor type-2B

1

4

High-throughput

0.691

High

1120207

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

12

High-throughput

0.691

High

1125491

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

12

High-throughput

0.691

High

1150275

TESK1
Dual specificity testis-specific protein kinase 1

1

1

High-throughput

0.691

High

1158383

CDC37
Hsp90 co-chaperone Cdc37

1

9

High-throughput

0.691

High

1161844

AMHR2
Anti-Muellerian hormone type-2 receptor

1

4

High-throughput

0.691

High

1243032

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

5

High-throughput

0.691

High

1243052

MYO10
Unconventional myosin-X

1

6

High-throughput

0.691

High

1243067

FEM1B
Protein fem-1 homolog B

1

7

High-throughput

0.691

High

1145995

K1H1
Keratin, type I cuticular Ha1

3

13

High-throughput

0.665

High

1025816

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.656

High

355082

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

17

High-throughput

0.628

High

1243019

TSYL6
Testis-specific Y-encoded-like protein 6

2

5

High-throughput

0.628

High

692724

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.618

High

1243007

BTNL9
Butyrophilin-like protein 9

1

4

High-throughput

0.618

High

1243020

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

1

High-throughput

0.618

High

242029

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.618

High

440122

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

830937

CCNF
Cyclin-F

1

10

High-throughput

0.618

High

978096

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1122407

GIT2
ARF GTPase-activating protein GIT2

1

12

High-throughput

0.618

High

1243075

GIT1
ARF GTPase-activating protein GIT1

1

12

High-throughput

0.618

High

914433

EFNB2
Ephrin-B2

3

3

High-throughput

0.609

High

1063351

GOGA2
Golgin subfamily A member 2

2

8

High-throughput

0.606

High

1205830

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

11

High-throughput

0.606

High

1243017

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

1

High-throughput

0.606

High

1243050

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

217123

MS18B
Protein Mis18-beta

1

0

High-throughput

0.586

High

1202052

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

1202089

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.575

High

1153469

EFNB3
Ephrin-B3

2

3

High-throughput

0.574

High

1229815

CYTSA
Cytospin-A

2

8

High-throughput

0.574

High

1243021

PNMA1
Paraneoplastic antigen Ma1

2

4

High-throughput

0.553

High

1237899

PHLB3
Pleckstrin homology-like domain family B member 3

1

9

High-throughput

0.553

High

1243048

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.553

High

124799

AIP
AH receptor-interacting protein

1

8

High-throughput

0.536

High

136402

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.536

High

160530

IRS4
Insulin receptor substrate 4

1

6

High-throughput

0.536

High

175085

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

300775

KRT38
Keratin, type I cuticular Ha8

1

13

High-throughput

0.536

High

316401

RMP
Unconventional prefoldin RPB5 interactor 1

1

2

High-throughput

0.536

High

325890

UBR5
E3 ubiquitin-protein ligase UBR5

1

15

High-throughput

0.536

High

331060

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.536

High

359676

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

445205

S10A6
Protein S100-A6

1

7

High-throughput

0.536

High

549618

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

11

High-throughput

0.536

High

655844

TBG1
Tubulin gamma-1 chain

1

14

High-throughput

0.536

High

686824

S10A4
Protein S100-A4

1

7

High-throughput

0.536

High

697565

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.536

High

722994

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.536

High

930945

HSP72
Heat shock-related 70 kDa protein 2

1

7

High-throughput

0.536

High

977525

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

11

High-throughput

0.536

High

986502

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.536

High

994265

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

11

High-throughput

0.536

High

1010858

TMF1
TATA element modulatory factor

1

9

High-throughput

0.536

High

1022880

EFNB1
Ephrin-B1

1

3

High-throughput

0.536

High

1027530

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

High-throughput

0.536

High

1032488

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.536

High

1092890

STRN3
Striatin-3

1

6

High-throughput

0.536

High

1214710

ATD3B
ATPase family AAA domain-containing protein 3B

1

11

High-throughput

0.536

High

1243012

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

7

High-throughput

0.536

High

1243023

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

1

High-throughput

0.536

High

1243027

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.536

High

1243041

OPALI
Opalin

1

2

High-throughput

0.536

High

1243042

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

1243043

NP1L4
Nucleosome assembly protein 1-like 4

1

5

High-throughput

0.536

High

1243044

TBA1C
Tubulin alpha-1C chain

1

12

High-throughput

0.536

High

1243046

TXNIP
Thioredoxin-interacting protein

1

7

High-throughput

0.536

High

1243049

RPAP3
RNA polymerase II-associated protein 3

1

6

High-throughput

0.536

High

1243053

WDR6
tRNA

1

18

High-throughput

0.536

High

1243063

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.536

High

1243066

KLH21
Kelch-like protein 21

1

6

High-throughput

0.536

High

1243071

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.536

High

1243073

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.536

High

1243077

MYO5A
Unconventional myosin-Va

1

5

High-throughput

0.536

High

163566

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.513

High

191343

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

894831

EMD
Emerin

1

0

High-throughput

0.513

High

1007869

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

1102994

CENPR
Centromere protein R

1

0

High-throughput

0.513

High

1243016

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1243018

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1243030

SKA1
SKA complex subunit 1

1

0

High-throughput

0.513

High

1243036

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.513

High

1243039

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1243057

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.513

High

1243062

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

1243078

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.513

High

228830

SCO2
Protein SCO2 homolog, mitochondrial

1

2

High-throughput

0.489

High

483588

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

1

High-throughput

0.489

High

706174

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

749782

CADH5
Cadherin-5

1

4

High-throughput

0.489

High

847567

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.489

High

880157

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.489

High

1120910

TRI29
Tripartite motif-containing protein 29

1

9

High-throughput

0.489

High

1179799

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1243015

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.489

High

1243033

I17RA
Interleukin-17 receptor A

1

2

High-throughput

0.489

High

1243059

PCD10
Protocadherin-10

1

1

High-throughput

0.489

High

1243068

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

2

High-throughput

0.489

High

1243070

PNMA2
Paraneoplastic antigen Ma2

1

4

High-throughput

0.489

High

1243080

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.489

High

128446

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

High-throughput

0.479

High

132736

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

8

High-throughput

0.479

High

192935

CLOCK
Circadian locomoter output cycles protein kaput

1

7

High-throughput

0.479

High

228601

STRN
Striatin

1

9

High-throughput

0.479

High

884353

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

942688

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

Small-scale

0.479

High

959603

MAX
Protein max

1

5

High-throughput

0.479

High

1045412

TF65
Transcription factor p65

1

11

High-throughput

0.479

High

1144832

RABE1
Rab GTPase-binding effector protein 1

1

10

High-throughput

0.479

High

1196269

GRAP1
GRIP1-associated protein 1

1

6

High-throughput

0.479

High

1243011

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1243024

GOGA5
Golgin subfamily A member 5

1

10

High-throughput

0.479

High

1243025

CCHCR
Coiled-coil alpha-helical rod protein 1

1

6

High-throughput

0.479

High

1243038

SNX27
Sorting nexin-27

1

16

High-throughput

0.479

High

1243045

NUF2
Kinetochore protein Nuf2

1

6

High-throughput

0.479

High

1243055

HM20A
High mobility group protein 20A

1

8

High-throughput

0.479

High

1243056

BRD7
Bromodomain-containing protein 7

1

10

High-throughput

0.479

High

1243065

RABX5
Rab5 GDP/GTP exchange factor

1

1

High-throughput

0.479

High

1243069

RCOR1
REST corepressor 1

1

3

High-throughput

0.479

High

1243076

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.479

High

340349

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.458

High

503609

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

974942

TYB4
Thymosin beta-4

1

0

High-throughput

0.458

High

1178205

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1217257

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.458

High

1239850

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1243010

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.458

High

1243028

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1243031

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1243035

VPS50
Syndetin

1

0

High-throughput

0.458

High

1243040

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.458

High

1243064

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.458

High

529971

TAU
Microtubule-associated protein tau

1

15

Small-scale

0.445

High

839467

PI4KA
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.445

High

1243009

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.445

High

1195652

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.437

High

1200038

EIPR1
EARP and GARP complex-interacting protein 1

1

2

High-throughput

0.437

High

1201124

CCD93
Coiled-coil domain-containing protein 93

1

4

High-throughput

0.437

High

1243014

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

14

High-throughput

0.437

High

1243029

PF21A
PHD finger protein 21A

1

1

High-throughput

0.437

High

1243060

HECW2
E3 ubiquitin-protein ligase HECW2

1

13

High-throughput

0.437

High

1133781

SL9A5
Sodium/hydrogen exchanger 5

1

1

High-throughput

0.407

High

1180737

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

1

High-throughput

0.407

High

239101

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

1243079

PCDGD
Protocadherin gamma-B1

2

0

High-throughput

0.328

High

1243061

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.316

High

124379

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

789143

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.279

Low

1220514

MIC13
MICOS complex subunit MIC13

1

0

High-throughput

0.279

Low

1243022

NGDN
Neuroguidin

1

0

High-throughput

0.279

Low

1243034

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.279

Low

1243047

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

1243058

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

85278

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

1211679

CC122
Coiled-coil domain-containing protein 122

1

0

High-throughput

0.249

Low

1243051

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1243054

TUFT1
Tuftelin

1

0

High-throughput

0.249

Low

1243037

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025