HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: EPHA5 (P54756)
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Gene: EPHA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030424 - axon GO:0030425 - dendrite
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 1037
+	Hs
		239797 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA3_HUMAN (51-1037): 0: 1232: 66.53
+	Hs
		239879 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA4_HUMAN (33-1035): 0: 1223: 62.04
+	Hs
		240007 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA7_HUMAN (37-1035): 0: 1222: 62.69
+	Hs
		239878 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB1_HUMAN (59-1034): 0: 1217: 55.98
+	Hs
		239798 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB2_HUMAN (60-1034): 0: 1209: 56.80
+	Hs
		240236 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA6_HUMAN (28-1034): 0: 1198: 57.03
+	Hs
		239876 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB3_HUMAN (57-1037): 0: 1155: 54.13
+	Hs
		239956 HCN1_HUMAN (1-890): 0: 684: 100.00		TYRO3_HUMAN (293-975): 8.48e-147: 462: 21.19
+	Hs
		239707 HCN1_HUMAN (1-890): 0: 684: 100.00		FYN_HUMAN (669-933): 3.12e-64: 229: 44.20
+	Hs
		412401 HCN2_HUMAN (3-812): 0: 576: 63.68		FYN_HUMAN (669-933): 3.12e-64: 229: 44.20
+	Hs
		412422 HCN4_HUMAN (15-885): 3.07e-173: 536: 57.64		FYN_HUMAN (669-933): 3.12e-64: 229: 44.20