Protein: SPSB2
SPRY domain-containing SOCS box protein 2 (SSB-2) (Gene-rich cluster protein C9)

Gene: SPSB2
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q99619

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1371842

CUL5
Cullin-5

6

20

Small-scale

0.945

High

1147110

ELOC
Elongin-C

4

6

Small-scale

0.910

High

1364862

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

10

High-throughput

0.819

High

766222

NOS2
Nitric oxide synthase, inducible

6

7

Small-scale

0.741

High

710884

EPHB2
Ephrin type-B receptor 2

4

13

High-throughput

0.691

High

1405797

TTC1
Tetratricopeptide repeat protein 1

4

14

High-throughput

0.691

High

174268

ARHGA
Rho guanine nucleotide exchange factor 10

4

17

High-throughput

0.683

High

1147257

ELOB
Elongin-B

3

4

Small-scale

0.667

High

1405983

RBX2
RING-box protein 2

3

9

Small-scale

0.662

High

1394516

PAWR
PRKC apoptosis WT1 regulator protein

2

4

Small-scale

0.619

High

1308401

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

19

High-throughput

0.618

High

1115020

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

1160988

NRF1
Nuclear respiratory factor 1

2

1

High-throughput

0.606

High

907555

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

19

High-throughput

0.601

High

1405977

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

15

High-throughput

0.601

High

1405973

ANM1
Protein arginine N-methyltransferase 1

1

13

High-throughput

0.573

High

1198275

FND3B
Fibronectin type III domain-containing protein 3B

2

13

High-throughput

0.553

High

1392037

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

1

High-throughput

0.553

High

320891

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

2

10

High-throughput

0.549

High

626018

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

2

8

High-throughput

0.549

High

1120802

DSG2
Desmoglein-2

2

19

High-throughput

0.549

High

1249980

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

2

10

High-throughput

0.549

High

1405975

DDA1
DET1- and DDB1-associated protein 1

2

2

High-throughput

0.549

High

1380833

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.541

High

335174

ARI2
E3 ubiquitin-protein ligase ARIH2

1

15

High-throughput

0.536

High

991687

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.536

High

1129487

PUM1
Pumilio homolog 1

1

7

High-throughput

0.536

High

1347147

WDR48
WD repeat-containing protein 48

1

15

High-throughput

0.536

High

1391911

RN185
E3 ubiquitin-protein ligase RNF185

1

14

High-throughput

0.536

High

1405979

DOCK5
Dedicator of cytokinesis protein 5

1

10

High-throughput

0.536

High

1405982

FANCI
Fanconi anemia group I protein

1

2

High-throughput

0.536

High

242698

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.515

High

474923

VIME
Vimentin

1

10

High-throughput

0.515

High

593786

PECA1
Platelet endothelial cell adhesion molecule

1

16

High-throughput

0.515

High

957654

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

9

High-throughput

0.515

High

1405985

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

422966

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

1325354

GLT15
Polypeptide N-acetylgalactosaminyltransferase 15

1

6

High-throughput

0.494

High

1405976

TRI55
Tripartite motif-containing protein 55

1

19

High-throughput

0.494

High

469185

SRPRA
Signal recognition particle receptor subunit alpha

1

4

High-throughput

0.489

High

631843

NR1D1
Nuclear receptor subfamily 1 group D member 1

1

11

High-throughput

0.489

High

945909

INHBE
Inhibin beta E chain

1

5

High-throughput

0.489

High

1062185

PCDH1
Protocadherin-1

1

20

High-throughput

0.489

High

1197270

MBRL
Membralin

1

2

High-throughput

0.489

High

1198967

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

7

High-throughput

0.489

High

1217070

MCAF2
Activating transcription factor 7-interacting protein 2

1

1

High-throughput

0.489

High

1394721

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

13

High-throughput

0.489

High

1405974

CNPY3
Protein canopy homolog 3

1

2

High-throughput

0.489

High

1405978

ANTR1
Anthrax toxin receptor 1

1

10

High-throughput

0.489

High

1405980

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

20

High-throughput

0.489

High

1405984

MAN1
Inner nuclear membrane protein Man1

1

10

High-throughput

0.489

High

1405986

SRPRB
Signal recognition particle receptor subunit beta

1

12

High-throughput

0.489

High

981935

RL23
Large ribosomal subunit protein uL14

1

2

High-throughput

0.479

High

1405981

DDX4
Probable ATP-dependent RNA helicase DDX4

1

13

Small-scale

0.472

High

109499

G5E9A7
DM1 locus, WD repeat containing

1

16

High-throughput

0.470

High

246114

KIF1B
Kinesin-like protein KIF1B

1

20

High-throughput

0.470

High

1243356

Q6P9E2
RECK protein

1

1

High-throughput

0.470

High

208556

PJA2
E3 ubiquitin-protein ligase Praja-2

1

6

High-throughput

0.445

High

336567

PIGN
GPI ethanolamine phosphate transferase 1

1

6

High-throughput

0.445

High

856882

BAG6
Large proline-rich protein BAG6

1

12

High-throughput

0.445

High

932036

EPHB1
Ephrin type-B receptor 1

1

13

High-throughput

0.445

High

1339839

PJA1
E3 ubiquitin-protein ligase Praja-1

1

6

High-throughput

0.445

High

352035

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

1

1

High-throughput

0.439

High

472121

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.437

High

96810

E9PB39
Rho guanine nucleotide exchange factor 10

1

20

High-throughput

0.407

High

239877

PCDH7
Protocadherin-7

1

20

High-throughput

0.407

High

618284

CADH2
Cadherin-2

1

19

High-throughput

0.407

High

937522

CADH4
Cadherin-4

1

19

High-throughput

0.407

High

1250362

FAT4
Protocadherin Fat 4

1

20

High-throughput

0.407

High

1394951

MAGD4
Melanoma-associated antigen D4

1

9

High-throughput

0.407

High

1395502

PCD16
Protocadherin-16

1

20

High-throughput

0.407

High

1405297

PKP4
Plakophilin-4

1

14

High-throughput

0.407

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025