Protein: SPSB4
SPRY domain-containing SOCS box protein 4 (SSB-4)

Gene: SPSB4
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q96A44

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1147089

ELOC
Elongin-C

5

6

Small-scale

0.933

High

1371823

CUL5
Cullin-5

5

20

Small-scale

0.925

High

827881

STAT3
Signal transducer and activator of transcription 3

1

7

High-throughput

0.691

High

1115347

CUL4B
Cullin-4B

1

20

High-throughput

0.691

High

1382360

SPSB1
SPRY domain-containing SOCS box protein 1

1

14

High-throughput

0.691

High

1382368

ASPP1
Apoptosis-stimulating of p53 protein 1

1

16

High-throughput

0.691

High

1382391

SH2B1
SH2B adapter protein 1

1

11

High-throughput

0.691

High

1147233

ELOB
Elongin-B

3

4

Small-scale

0.667

High

710874

EPHB2
Ephrin type-B receptor 2

3

13

Small-scale

0.650

High

1382364

PAWR
PRKC apoptosis WT1 regulator protein

2

4

Small-scale

0.619

High

173735

BTAF1
TATA-binding protein-associated factor 172

1

15

High-throughput

0.618

High

1308399

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

20

High-throughput

0.618

High

631841

NR1D1
Nuclear receptor subfamily 1 group D member 1

2

11

Small-scale

0.611

High

1382398

RBX2
RING-box protein 2

2

10

Small-scale

0.611

High

174263

ARHGA
Rho guanine nucleotide exchange factor 10

2

20

High-throughput

0.601

High

208546

PJA2
E3 ubiquitin-protein ligase Praja-2

2

6

High-throughput

0.601

High

932035

EPHB1
Ephrin type-B receptor 1

2

13

High-throughput

0.601

High

1127589

FAT1
Protocadherin Fat 1

2

19

High-throughput

0.601

High

1129475

PUM1
Pumilio homolog 1

2

7

High-throughput

0.601

High

1339827

PJA1
E3 ubiquitin-protein ligase Praja-1

2

6

High-throughput

0.601

High

1382372

TTC1
Tetratricopeptide repeat protein 1

2

14

High-throughput

0.601

High

1382377

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

14

High-throughput

0.601

High

1382392

FANCI
Fanconi anemia group I protein

2

2

High-throughput

0.601

High

1382399

FBX5
F-box only protein 5

2

1

High-throughput

0.601

High

766215

NOS2
Nitric oxide synthase, inducible

2

7

Small-scale

0.595

High

239872

PCDH7
Protocadherin-7

2

20

High-throughput

0.549

High

320886

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

2

12

High-throughput

0.549

High

469163

SRPRA
Signal recognition particle receptor subunit alpha

2

5

High-throughput

0.549

High

641971

CD9
CD9 antigen

2

5

High-throughput

0.549

High

1062180

PCDH1
Protocadherin-1

2

20

High-throughput

0.549

High

1120791

DSG2
Desmoglein-2

2

20

High-throughput

0.549

High

1197263

MBRL
Membralin

2

2

High-throughput

0.549

High

1249977

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

2

12

High-throughput

0.549

High

1250359

FAT4
Protocadherin Fat 4

2

20

High-throughput

0.549

High

1382366

MAGD4
Melanoma-associated antigen D4

2

12

High-throughput

0.549

High

1382367

PCD16
Protocadherin-16

2

20

High-throughput

0.549

High

1382369

SFXN2
Sideroflexin-2

2

4

High-throughput

0.549

High

1382388

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

20

High-throughput

0.549

High

1382395

SACS
Sacsin

2

1

High-throughput

0.549

High

1382401

PCDGK
Protocadherin gamma-C3

2

17

High-throughput

0.549

High

246306

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

1

High-throughput

0.536

High

257061

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

8

High-throughput

0.536

High

287719

KS6A5
Ribosomal protein S6 kinase alpha-5

1

13

High-throughput

0.536

High

335162

ARI2
E3 ubiquitin-protein ligase ARIH2

1

16

High-throughput

0.536

High

336562

PIGN
GPI ethanolamine phosphate transferase 1

1

6

High-throughput

0.536

High

577848

PLAK
Junction plakoglobin

1

18

High-throughput

0.536

High

719650

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

2

High-throughput

0.536

High

764951

CTNB1
Catenin beta-1

1

14

High-throughput

0.536

High

1060558

KLC1
Kinesin light chain 1

1

11

High-throughput

0.536

High

1087023

KIF5A
Kinesin heavy chain isoform 5A

1

20

High-throughput

0.536

High

1093025

CDC16
Cell division cycle protein 16 homolog

1

10

High-throughput

0.536

High

1121138

UBE4A
Ubiquitin conjugation factor E4 A

1

3

High-throughput

0.536

High

1122810

DOCK1
Dedicator of cytokinesis protein 1

1

19

High-throughput

0.536

High

1290924

TAXB1
Tax1-binding protein 1

1

20

High-throughput

0.536

High

1292090

PARG
Poly(ADP-ribose) glycohydrolase

1

1

High-throughput

0.536

High

1311084

UBR1
E3 ubiquitin-protein ligase UBR1

1

3

High-throughput

0.536

High

1337301

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

8

High-throughput

0.536

High

1348109

PUM2
Pumilio homolog 2

1

7

High-throughput

0.536

High

1353401

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

20

High-throughput

0.536

High

1365441

TBCD5
TBC1 domain family member 5

1

8

High-throughput

0.536

High

1371045

ARHG2
Rho guanine nucleotide exchange factor 2

1

17

High-throughput

0.536

High

1382362

RN185
E3 ubiquitin-protein ligase RNF185

1

14

High-throughput

0.536

High

1382371

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

13

High-throughput

0.536

High

1382373

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.536

High

1382378

LHPP
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

1

3

High-throughput

0.536

High

1382379

KLC2
Kinesin light chain 2

1

12

High-throughput

0.536

High

1382380

SIK2
Serine/threonine-protein kinase SIK2

1

8

High-throughput

0.536

High

1382381

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

12

High-throughput

0.536

High

1382382

DOCK5
Dedicator of cytokinesis protein 5

1

13

High-throughput

0.536

High

1382383

LRC40
Leucine-rich repeat-containing protein 40

1

10

High-throughput

0.536

High

1382385

AGO3
Protein argonaute-3

1

7

High-throughput

0.536

High

1382400

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.536

High

1382403

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

16

High-throughput

0.536

High

1126832

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.513

High

1136667

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.513

High

1217712

RN220
E3 ubiquitin-protein ligase RNF220

1

0

High-throughput

0.513

High

1382361

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

822803

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

161071

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

8

High-throughput

0.489

High

167757

PCD17
Protocadherin-17

1

20

High-throughput

0.489

High

208714

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

9

High-throughput

0.489

High

333695

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

2

High-throughput

0.489

High

572327

CBPM
Carboxypeptidase M

1

3

High-throughput

0.489

High

618277

CADH2
Cadherin-2

1

20

High-throughput

0.489

High

626014

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

9

High-throughput

0.489

High

1085099

KIF1A
Kinesin-like protein KIF1A

1

20

High-throughput

0.489

High

1121587

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

1

High-throughput

0.489

High

1149536

CDSN
Corneodesmosin

1

1

High-throughput

0.489

High

1150063

MARE2
Microtubule-associated protein RP/EB family member 2

1

3

High-throughput

0.489

High

1164498

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.489

High

1198964

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

7

High-throughput

0.489

High

1204939

MTX3
Metaxin-3

1

2

High-throughput

0.489

High

1276141

NUP54
Nucleoporin p54

1

8

High-throughput

0.489

High

1330125

PCD20
Protocadherin-20

1

20

High-throughput

0.489

High

1346678

PCD19
Protocadherin-19

1

20

High-throughput

0.489

High

1351803

FAT3
Protocadherin Fat 3

1

20

High-throughput

0.489

High

1353749

SHRM3
Protein Shroom3

1

14

High-throughput

0.489

High

1369098

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

7

High-throughput

0.489

High

1382365

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

16

High-throughput

0.489

High

1382370

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

5

High-throughput

0.489

High

1382374

NUP58
Nucleoporin p58/p45

1

3

High-throughput

0.489

High

1382375

DDA1
DET1- and DDB1-associated protein 1

1

2

High-throughput

0.489

High

1382384

SFXN1
Sideroflexin-1

1

4

High-throughput

0.489

High

1382386

PCDH9
Protocadherin-9

1

20

High-throughput

0.489

High

1382387

PCD18
Protocadherin-18

1

20

High-throughput

0.489

High

1382389

NGRN
Neugrin

1

2

High-throughput

0.489

High

1382393

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

20

High-throughput

0.489

High

1382394

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

20

High-throughput

0.489

High

1382396

FPRP
Prostaglandin F2 receptor negative regulator

1

15

High-throughput

0.489

High

1382397

PCD10
Protocadherin-10

1

20

High-throughput

0.489

High

1382404

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.489

High

1382405

KCTD3
BTB/POZ domain-containing protein KCTD3

1

9

High-throughput

0.489

High

1382409

PCDGL
Protocadherin gamma-C4

1

18

High-throughput

0.489

High

1382415

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

4

High-throughput

0.489

High

1382416

SRPRB
Signal recognition particle receptor subunit beta

1

13

High-throughput

0.489

High

1382390

DDX4
Probable ATP-dependent RNA helicase DDX4

1

13

Small-scale

0.472

High

250000

OGA
Protein O-GlcNAcase

1

1

High-throughput

0.445

High

856849

BAG6
Large proline-rich protein BAG6

1

16

High-throughput

0.445

High

1289807

AACS
Acetoacetyl-CoA synthetase

1

8

High-throughput

0.445

High

472110

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.437

High

369268

ANT3
Antithrombin-III

1

9

High-throughput

0.407

High

516708

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

14

High-throughput

0.407

High

937520

CADH4
Cadherin-4

1

20

High-throughput

0.407

High

937556

CAD11
Cadherin-11

1

20

High-throughput

0.407

High

1382376

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

1

High-throughput

0.407

High

1382402

PCDA6
Protocadherin alpha-6

1

16

High-throughput

0.407

High

1382406

PCDB2
Protocadherin beta-2

1

18

High-throughput

0.407

High

1382407

PCDBE
Protocadherin beta-14

1

17

High-throughput

0.407

High

1382408

PCDBD
Protocadherin beta-13

1

18

High-throughput

0.407

High

1382410

PCDGH
Protocadherin gamma-B5

1

20

High-throughput

0.407

High

1382411

PCDGD
Protocadherin gamma-B1

1

17

High-throughput

0.407

High

1382412

PCDG4
Protocadherin gamma-A4

1

17

High-throughput

0.407

High

1382413

PCDA8
Protocadherin alpha-8

1

17

High-throughput

0.407

High

1382414

PCDC2
Protocadherin alpha-C2

1

17

High-throughput

0.407

High

800026

COIL
Coilin

2

0

High-throughput

0.313

High

66646

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

239384

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.279

Low

1245447

CNST
Consortin

1

0

High-throughput

0.279

Low

1382363

TECT2
Tectonic-2

1

0

High-throughput

0.279

Low

1136753

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.232

Low

1314524

TM192
Transmembrane protein 192

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025