HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 745
+	Hs
		240896 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38
+	Hs
		765083 RNF14_HUMAN (177-464): 1.02e-68: 228: 22.04		CTNB1_HUMAN (1-731): 3.13e-172: 515: 67.38
+	Hs
		240238 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		CTND1_HUMAN (203-728): 3.16e-90: 305: 16.25
+	Hs
		142457 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IMA3_HUMAN (228-670): 8.24e-65: 226: 16.01
+	Hs
		138598 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IMA4_HUMAN (228-670): 1.86e-63: 222: 15.79
+	Hs
		241155 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IMA1_HUMAN (270-664): 9.2e-48: 179: 14.32
+	Hs
		240236 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IMA7_HUMAN (266-685): 6.6e-45: 171: 15.27
+	Hs
		179010 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		IMA6_HUMAN (273-659): 1.01e-40: 159: 13.95
+	Hs
		254219 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		CTND1_HUMAN (203-728): 3.16e-90: 305: 16.25
+	Hs
		242196 PRKN_HUMAN (1-465): 2.85e-136: 402: 100.00		ARMC8_HUMAN (135-530): 3.9e-16: 84.5: 19.12
+	Hs
		911089 HOIL1_HUMAN (12-448): 3.03e-67: 225: 16.36		IMA1_HUMAN (270-664): 9.2e-48: 179: 14.32
+	Hs
		911139 AKIB1_HUMAN (211-456): 1.1e-60: 215: 20.08		IMA1_HUMAN (270-664): 9.2e-48: 179: 14.32
+	At
		306055 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		IMPA4_ARATH (250-736): 2.32e-48: 181: 15.86
+	At
		1167893 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		IMPA1_ARATH (270-681): 2.92e-47: 177: 16.38
+	At
		102326 UBQ3_ARATH (1-77): 1.82e-30: 121: 31.17		IMPA2_ARATH (354-736): 1.63e-31: 131: 13.60