HitPredict

Interactor 1: OPHN1 (O60890)
Oligophrenin-1
Gene: OPHN1

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	9582072, 31871319
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization GO:0034329 - cell junction assembly GO:0043197 - dendritic spine GO:0045198 - establishment of epithelial cell apical/basal polarity and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 191
+	Hs
		245184 OPHN1_HUMAN (1-802): 0: 650: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		245183 OPHN1_HUMAN (1-802): 0: 650: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		63073 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		63065 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		63072 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		894587 RHG26_HUMAN (1-661): 0: 541: 50.45		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		901048 RHG26_HUMAN (1-661): 0: 541: 50.45		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		49630 RHG10_HUMAN (1-718): 9e-179: 534: 45.22		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		49631 RHG10_HUMAN (1-718): 9e-179: 534: 45.22		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Dm
		776930 RHGF_DROME (2-801): 2.98e-149: 465: 31.01		RAC1_DROME (1-191): 1.02e-81: 242: 69.27
+	Hs
		253311 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		253337 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		893974 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		900443 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		436289 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		200213 SRGP3_HUMAN (21-795): 1.53e-100: 337: 14.49		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		253333 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Mm
		892733 SRGP1_MOUSE (8-793): 1.52e-101: 339: 15.79		CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00
+	Mm
		1265268 SRGP1_MOUSE (8-793): 1.52e-101: 339: 15.79		RHOA_MOUSE (5-191): 9.99e-82: 242: 53.48
+	Hs
		253371 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82