HitPredict

Interactor 1: LRP4 (O75096)
Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)
Gene: LRP4

Interactor 2: AMRP (P30533)
Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)
Gene: LRPAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Alpha-2-MRAP_C~Ldl_recept_a, Alpha-2-MRAP_N~Ldl_recept_a
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1905 Hs			1 357
+	Hs
		351054 LDLR_HUMAN (3-352): 1.45e-52: 203: 33.33		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674662 LRP8_HUMAN (3-352): 8.37e-38: 157: 29.30		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674650 VLDLR_HUMAN (1-178): 3.03e-16: 87.1: 26.88		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Gg
		223338 LRP8_CHICK (3-265): 4.09e-31: 135: 29.43		O57378_CHICK (27-357): 1.68e-131: 381: 67.87
+	Hs
		674705 SORL_HUMAN (1615-1724): 2e-10: 68.6: 10.81		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674731 LRP1B_HUMAN (251-512): 5.06e-10: 67.4: 13.26		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674651 LRP2_HUMAN (273-499): 9.34e-10: 66.3: 15.45		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674653 LRP1_HUMAN (31-177): 6.59e-09: 63.6: 28.66		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Gg
		223337 VLDLR_CHICK (1-178): 9.38e-14: 79: 25.81		O57378_CHICK (27-357): 1.68e-131: 381: 67.87
+	Dm
		65980 A8JRC4_DROME (1614-1722): 6.73e-09: 63.2: 13.79		Q9VH64_DROME (15-357): 2.22e-98: 298: 31.84