HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 0.60 0.772

The method score is based on:

Property Details
Experiments 26506240, 20851351, 28018973, 30181396, 30923315, 30918250, 29789528, 33159601, 33482471, 37137416, 37500894, 16798748, 10228155, 10074433, 9990852, 17053147, 20531388, 18354482, 18851830, 22912335 and 37 others

more...
Identification Methods affinity chromatography technology, protein complementation assay, pull down, unspecified method, proximity labelling technology, enzymatic study, two hybrid, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 2 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 781
Hs

1 605
+ Mm
+ Hs
+ Hs
+ Hs
+ Xl
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025