HitPredict

Interactor 1: SOCS5 (O75159)
Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)
Gene: SOCS5

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 536 Hs			1 780
+	Mm
		222648 SOCS5_MOUSE (1-536): 0: 691: 94.40		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1263831 SOCS4_HUMAN (93-530): 4.74e-149: 436: 52.83		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1265273 SOCS4_MOUSE (93-529): 1.59e-150: 440: 51.14		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1322060 SOCS6_MOUSE (105-519): 5.9e-56: 198: 22.12		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		147544 SOCS6_HUMAN (148-519): 1.66e-51: 185: 22.11		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		146642 SOCS2_HUMAN (340-520): 2.98e-52: 178: 30.05		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193366 SOCS2_MOUSE (340-520): 3.29e-51: 175: 30.05		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146692 SOCS7_HUMAN (303-525): 1.14e-40: 156: 21.01		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		181885 SOCS1_HUMAN (365-520): 3.43e-43: 154: 25.00		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1257617 SOCS7_MOUSE (303-525): 7.58e-41: 157: 21.01		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1274062 CISH_HUMAN (297-520): 5.43e-41: 150: 21.76		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193357 SOCS1_MOUSE (365-520): 1.66e-42: 152: 25.00		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1143676 CISH_MOUSE (303-520): 1.66e-41: 151: 22.75		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146625 SOCS2_HUMAN (340-520): 2.98e-52: 178: 30.05		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1041644 SHB_HUMAN (233-487): 2.5e-44: 165: 15.29		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1042817 VAV3_HUMAN (267-480): 2.15e-40: 158: 18.39		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		855795 VAV2_HUMAN (278-480): 3.34e-39: 154: 16.67		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		147421 SOCS3_HUMAN (369-517): 1.38e-34: 131: 22.63		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		181856 SOCS1_HUMAN (365-520): 3.43e-43: 154: 25.00		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Hs
		1041477 CISH_HUMAN (297-520): 5.43e-41: 150: 21.76		CUL2_HUMAN (6-780): 0: 699: 26.36