HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11748221
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 770
+	Mm
		927926 HMGB1_MOUSE (1-174): 9.92e-46: 152: 100.00		TLE1_MOUSE (1-770): 0: 563: 97.15
+	Hs
		980642 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		817954 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980859 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		817955 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Dm
		558375 DICH_DROME (7-101): 3.34e-27: 108: 24.21		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Hs
		449697 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Mm
		925827 HMGB1_MOUSE (1-174): 9.92e-46: 152: 100.00		TLE5_MOUSE (1-200): 1.04e-91: 287: 64.50
+	Hs
		178916 TOX3_HUMAN (91-165): 4.65e-29: 115: 40.00		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		996930 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		NLE1_HUMAN (257-684): 2.37e-65: 227: 11.13
+	Hs
		449632 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		996881 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		TBL1R_HUMAN (558-769): 4.54e-47: 177: 15.65
+	Hs
		245594 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		643290 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		245575 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		903169 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		817868 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		197008 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		PRP4_HUMAN (535-761): 1.01e-11: 70.1: 26.92
+	Hs
		996824 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SNR40_HUMAN (507-675): 1.08e-09: 62.8: 28.18
+	Hs
		196970 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PRP4_HUMAN (535-761): 1.01e-11: 70.1: 26.92