HitPredict

Interactor 1: KDM4A (O75164)
Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)
Gene: KDM4A

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	34269483, 16732292, 16601153, 16415788
Identification Methods	enzymatic study, x-ray crystallography, unspecified method, surface plasmon resonance, far western blotting, pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1064 Hs			1 136
+	Hs
		256973 KDM4A_HUMAN (1-1064): 0: 1133: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		256963 KDM4A_HUMAN (1-1064): 0: 1133: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		935232 KDM4C_HUMAN (1-1064): 0: 1055: 53.47		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952622 KDM4C_HUMAN (1-1064): 0: 1055: 53.47		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174653 KDM4C_HUMAN (1-1064): 0: 1055: 53.47		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		301134 KDM4B_HUMAN (1-1064): 0: 1049: 49.95		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		301136 KDM4B_HUMAN (1-1064): 0: 1049: 49.95		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		301146 KDM4B_HUMAN (1-1064): 0: 1049: 49.95		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Dm
		356098 KDM4B_DROME (8-438): 2.8e-157: 480: 51.59		H3_DROME (1-136): 6.5e-61: 185: 99.27
+	Dm
		356095 KDM4A_DROME (5-465): 4.37e-155: 471: 48.33		H3_DROME (1-136): 6.5e-61: 185: 99.27
+	Sc
		765602 RPH1_YEAST (1-731): 5.06e-148: 463: 22.03		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		812506 JHD2_YEAST (25-449): 7.01e-107: 352: 22.03		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		876688 BRPF1_HUMAN (432-926): 5.25e-85: 301: 18.70		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		876690 BRPF1_HUMAN (432-926): 5.25e-85: 301: 18.70		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		876700 BRPF1_HUMAN (432-926): 5.25e-85: 301: 18.70		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Sp
		457185 LID2_SCHPO (34-475): 3.18e-85: 304: 14.96		H31_SCHPO (1-136): 3.54e-59: 181: 91.91
+	Sp
		498409 LID2_SCHPO (34-475): 3.18e-85: 304: 14.96		H33_SCHPO (1-136): 7.45e-58: 177: 91.18
+	Sc
		902038 GIS1_YEAST (4-312): 1.59e-87: 303: 27.94		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		319165 BRD1_HUMAN (484-925): 3.78e-79: 282: 19.65		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		828181 BRPF1_HUMAN (432-926): 5.25e-85: 301: 18.70		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00