HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.80	0.696

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 1342
+	Hs
		473368 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		ERBB3_HUMAN (1-1342): 0: 1390: 100.00
+	Hs
		641513 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		ERBB3_HUMAN (1-1342): 0: 1390: 100.00
+	Hs
		473422 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		ERBB4_HUMAN (1-1162): 0: 1154: 50.94
+	Hs
		840959 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		ERBB4_HUMAN (1-1162): 0: 1154: 50.94
+	Hs
		410540 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		ERBB2_HUMAN (25-1222): 0: 1075: 39.95
+	Hs
		410691 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		ERBB2_HUMAN (25-1222): 0: 1075: 39.95
+	Hs
		410519 LCK_HUMAN (1-125): 8.6e-41: 143: 19.08		ERBB2_HUMAN (25-1222): 0: 1075: 39.95
+	Hs
		362630 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		EGFR_HUMAN (18-1211): 0: 1060: 40.65
+	Hs
		362926 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		EGFR_HUMAN (18-1211): 0: 1060: 40.65
+	Hs
		362594 LCK_HUMAN (1-125): 8.6e-41: 143: 19.08		EGFR_HUMAN (18-1211): 0: 1060: 40.65
+	Hs
		362129 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		ABL1_HUMAN (696-1307): 2.1e-132: 438: 22.51
+	Hs
		362199 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		ABL1_HUMAN (696-1307): 2.1e-132: 438: 22.51
+	Hs
		710789 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		EPHB2_HUMAN (635-993): 3.15e-106: 364: 28.00
+	Hs
		710107 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		EPHA2_HUMAN (665-996): 2e-104: 357: 29.40
+	Hs
		840938 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		EPHA4_HUMAN (656-996): 1.23e-103: 355: 27.79
+	Hs
		473406 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		473378 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		ABL2_HUMAN (705-971): 7.72e-43: 173: 36.06
+	Hs
		840931 ABL2_HUMAN (1-127): 1.86e-40: 144: 27.48		ABL2_HUMAN (705-971): 7.72e-43: 173: 36.06
+	Hs
		473401 HCK_HUMAN (1-127): 5.73e-42: 146: 20.30		FAK1_HUMAN (713-992): 4.45e-41: 167: 32.19
+	Hs
		116829 LCK_HUMAN (1-125): 8.6e-41: 143: 19.08		I6L996_HUMAN (713-992): 1.5e-41: 166: 32.19