HitPredict

Interactor 1: DNJA2 (O60884)
DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)
Gene: DNAJA2

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 393
+	Hs
		258787 DNJA2_HUMAN (1-412): 1.15e-169: 483: 100.00		MP2K2_HUMAN (1-391): 2.16e-123: 364: 79.40
+	Hs
		727703 DNJA1_HUMAN (4-410): 1.4e-154: 444: 54.77		MP2K2_HUMAN (1-391): 2.16e-123: 364: 79.40
+	Hs
		727777 DNJA1_HUMAN (4-410): 1.4e-154: 444: 54.77		STK4_HUMAN (37-369): 3.3e-111: 336: 30.06
+	Dm
		1173813 Q9VFV9_DROME (4-409): 9.3e-136: 396: 47.04		DSOR1_DROME (12-392): 3.46e-125: 368: 61.94
+	Sc
		441050 MAS5_YEAST (4-412): 1.02e-144: 419: 46.73		KAPA_YEAST (2-390): 1.15e-115: 344: 18.69
+	Hs
		258857 DNJA2_HUMAN (1-412): 1.15e-169: 483: 100.00		MP2K5_HUMAN (48-379): 4.37e-84: 265: 42.34
+	At
		199460 DNAJ3_ARATH (5-412): 1.72e-138: 404: 48.91		CIPKB_ARATH (67-372): 1.58e-110: 332: 21.66
+	Dm
		1303722 Q9VFV9_DROME (4-409): 9.3e-136: 396: 47.04		AKT1_DROME (45-389): 5.35e-111: 339: 19.77
+	At
		1081942 Q0WN54_ARATH (8-363): 5.91e-118: 354: 34.87		MPK4_ARATH (71-393): 1.71e-125: 368: 18.98
+	Hs
		783641 DNJA3_HUMAN (2-395): 1.68e-118: 355: 26.96		MP2K2_HUMAN (1-391): 2.16e-123: 364: 79.40
+	At
		1081943 Q0WN54_ARATH (8-363): 5.91e-118: 354: 34.87		MPK5_ARATH (71-393): 2.24e-120: 355: 18.07
+	Hs
		727781 DNJA1_HUMAN (4-410): 1.4e-154: 444: 54.77		MP2K5_HUMAN (48-379): 4.37e-84: 265: 42.34
+	Hs
		258799 DNJA2_HUMAN (1-412): 1.15e-169: 483: 100.00		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	At
		1081941 Q0WN54_ARATH (8-363): 5.91e-118: 354: 34.87		MPK2_ARATH (38-376): 1.53e-115: 342: 19.25
+	At
		1081944 Q0WN54_ARATH (8-363): 5.91e-118: 354: 34.87		MPK7_ARATH (40-383): 2.8e-115: 342: 18.13
+	Hs
		727717 DNJA1_HUMAN (4-410): 1.4e-154: 444: 54.77		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Sc
		675818 MAS5_YEAST (4-412): 1.02e-144: 419: 46.73		MKK2_YEAST (46-361): 4.04e-55: 191: 37.50
+	Sc
		671598 SCJ1_YEAST (10-339): 1.02e-51: 179: 37.75		HOG1_YEAST (66-393): 1.54e-121: 360: 21.15
+	Hs
		858722 DJB11_HUMAN (2-355): 2.41e-108: 325: 35.85		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Sc
		671599 SCJ1_YEAST (10-339): 1.02e-51: 179: 37.75		MKK2_YEAST (46-361): 4.04e-55: 191: 37.50