Protein: MKK2
MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)

Gene: MKK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 60
UniProt ID: P32491

Gene Ontology (top 5):
GO:0000196 - cell integrity MAPK cascade
GO:0000425 - pexophagy
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738071

SLT2
Mitogen-activated protein kinase SLT2/MPK1

7

20

Small-scale

0.970

High

738072

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

3

16

Small-scale

0.870

High

736068

ARP2
Actin-related protein 2

1

12

High-throughput

0.691

High

738055

KDX1
Serine/threonine-protein kinase KDX1

1

20

High-throughput

0.691

High

738081

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

11

High-throughput

0.691

High

671599

SCJ1
DnaJ-related protein SCJ1

1

14

High-throughput

0.646

High

675818

MAS5
Mitochondrial protein import protein MAS5

1

15

High-throughput

0.646

High

738070

ACT
Actin

1

10

High-throughput

0.646

High

738056

RGD1
RHO GTPase-activating protein RGD1

2

5

High-throughput

0.628

High

531277

METK1
S-adenosylmethionine synthase 1

2

1

High-throughput

0.618

High

673086

RNQ1
[PIN+] prion protein RNQ1

2

0

High-throughput

0.602

High

738061

SSB2
Ribosome-associated molecular chaperone SSB2

2

20

High-throughput

0.552

High

738076

CYK2
Cytokinesis protein 2

1

6

High-throughput

0.541

High

479971

PRTB
Cerevisin

1

2

High-throughput

0.536

High

598828

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

7

High-throughput

0.536

High

632787

DBP5
ATP-dependent RNA helicase DBP5

1

20

High-throughput

0.536

High

672287

RV161
Reduced viability upon starvation protein 161

1

4

High-throughput

0.536

High

684611

CDC20
APC/C activator protein CDC20

1

17

High-throughput

0.536

High

705748

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

5

High-throughput

0.536

High

721773

XPO1
Exportin-1

1

17

High-throughput

0.536

High

738053

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

4

High-throughput

0.536

High

738054

GCN1
eIF-2-alpha kinase activator GCN1

1

19

High-throughput

0.536

High

738057

RPN1
26S proteasome regulatory subunit RPN1

1

4

High-throughput

0.536

High

738060

RV167
Reduced viability upon starvation protein 167

1

9

High-throughput

0.536

High

738074

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.536

High

738075

KU80
ATP-dependent DNA helicase II subunit 2

1

7

High-throughput

0.536

High

738069

NST1
Stress response protein NST1

1

20

Small-scale

0.515

High

738066

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

738067

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.513

High

738079

PBP4
Protein PBP4

1

0

High-throughput

0.513

High

654709

SPA2
Protein SPA2

1

11

Small-scale

0.508

High

738078

SPH1
Protein SPH1

1

5

Small-scale

0.508

High

358985

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

6

High-throughput

0.500

High

359442

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.500

High

366973

ATPB
ATP synthase subunit beta, mitochondrial

1

10

High-throughput

0.500

High

386631

TBB
Tubulin beta chain

1

20

High-throughput

0.500

High

405059

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.500

High

452858

ATPA
ATP synthase subunit alpha, mitochondrial

1

11

High-throughput

0.500

High

486092

TBA1
Tubulin alpha-1 chain

1

20

High-throughput

0.500

High

592100

VATB
V-type proton ATPase subunit B

1

11

High-throughput

0.500

High

644733

CLH
Clathrin heavy chain

1

7

High-throughput

0.500

High

701671

URA7
CTP synthase 1

1

3

High-throughput

0.500

High

738064

MPG1
Mannose-1-phosphate guanyltransferase

1

4

High-throughput

0.500

High

738080

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.500

High

586441

PCNA
Proliferating cell nuclear antigen

1

6

High-throughput

0.489

High

738063

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

4

High-throughput

0.489

High

738077

RPN7
26S proteasome regulatory subunit RPN7

1

4

High-throughput

0.489

High

738059

YHS2
MIP18 family protein YHR122W

1

1

High-throughput

0.457

High

456363

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.457

High

661597

MPCP
Mitochondrial phosphate carrier protein

1

13

High-throughput

0.457

High

673484

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

4

High-throughput

0.457

High

510307

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

544180

SSB1
Ribosome-associated molecular chaperone SSB1

1

20

High-throughput

0.445

High

738058

SSZ1
Ribosome-associated complex subunit SSZ1

1

18

High-throughput

0.445

High

738068

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.438

High

706513

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

738073

MLP1
Protein MLP1

1

20

High-throughput

0.437

High

738065

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

585542

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

738062

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025