Protein: MP2K5
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)

Gene: MP2K5, MAP2K5
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q13163

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1097109

M3K3
Mitogen-activated protein kinase kinase kinase 3

10

16

Small-scale

0.981

High

1097125

M3K2
Mitogen-activated protein kinase kinase kinase 2

9

16

Small-scale

0.978

High

1097089

MK07
Mitogen-activated protein kinase 7

7

20

Small-scale

0.974

High

1097092

SQSTM
Sequestosome-1

7

9

Small-scale

0.966

High

461430

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

468326

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

1097088

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

3

16

Small-scale

0.840

High

1097096

CDC37
Hsp90 co-chaperone Cdc37

4

11

High-throughput

0.797

High

835659

KPCI
Protein kinase C iota type

2

20

Small-scale

0.754

High

1051218

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.747

High

258857

DNJA2
DnaJ homolog subfamily A member 2

2

18

High-throughput

0.737

High

727781

DNJA1
DnaJ homolog subfamily A member 1

2

18

High-throughput

0.737

High

1097101

ZN620
Zinc finger protein 620

2

3

High-throughput

0.700

High

1097111

ZN426
Zinc finger protein 426

2

6

High-throughput

0.700

High

1097115

DUS21
Dual specificity protein phosphatase 21

2

10

High-throughput

0.700

High

1097128

MRCKB
Serine/threonine-protein kinase MRCK beta

1

20

High-throughput

0.698

High

400757

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.647

High

410807

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

472052

MET
Hepatocyte growth factor receptor

1

13

High-throughput

0.647

High

521333

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.647

High

549138

CDK4
Cyclin-dependent kinase 4

1

20

High-throughput

0.647

High

593353

PGFRA
Platelet-derived growth factor receptor alpha

1

11

High-throughput

0.647

High

648497

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.647

High

710215

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.647

High

728207

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

High-throughput

0.647

High

858642

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

17

High-throughput

0.647

High

912499

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

19

High-throughput

0.647

High

1025335

CDK6
Cyclin-dependent kinase 6

1

20

High-throughput

0.647

High

1097095

STK11
Serine/threonine-protein kinase STK11

1

16

High-throughput

0.647

High

1097113

GLIS2
Zinc finger protein GLIS2

1

12

High-throughput

0.647

High

1097120

LATS2
Serine/threonine-protein kinase LATS2

1

17

High-throughput

0.647

High

1097118

PAR6A
Partitioning defective 6 homolog alpha

1

7

Small-scale

0.637

High

613017

EGR1
Early growth response protein 1

1

7

High-throughput

0.618

High

891507

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.618

High

987603

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

1097112

SCRT1
Transcriptional repressor scratch 1

1

12

High-throughput

0.618

High

1097119

SCRT2
Transcriptional repressor scratch 2

1

8

High-throughput

0.618

High

1097103

LNX2
Ligand of Numb protein X 2

3

10

High-throughput

0.601

High

507910

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

High-throughput

0.579

High

718808

CCND2
G1/S-specific cyclin-D2

1

10

High-throughput

0.579

High

842913

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

20

High-throughput

0.579

High

842955

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

20

High-throughput

0.579

High

1097100

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

13

High-throughput

0.574

High

191627

MAGB2
Melanoma-associated antigen B2

2

3

High-throughput

0.571

High

415535

HSPB1
Heat shock protein beta-1

2

9

High-throughput

0.571

High

457406

TBB5
Tubulin beta chain

2

20

High-throughput

0.571

High

537087

HSP7C
Heat shock cognate 71 kDa protein

2

18

High-throughput

0.571

High

600802

HSP76
Heat shock 70 kDa protein 6

2

19

High-throughput

0.571

High

610640

TCPA
T-complex protein 1 subunit alpha

2

16

High-throughput

0.571

High

680341

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

2

8

High-throughput

0.571

High

821329

TCPZ
T-complex protein 1 subunit zeta

2

15

High-throughput

0.571

High

875938

TCPE
T-complex protein 1 subunit epsilon

2

19

High-throughput

0.571

High

881900

TCPG
T-complex protein 1 subunit gamma

2

19

High-throughput

0.571

High

899018

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.571

High

899368

TCPD
T-complex protein 1 subunit delta

2

14

High-throughput

0.571

High

996927

TBA4A
Tubulin alpha-4A chain

2

20

High-throughput

0.571

High

997309

TBB4B
Tubulin beta-4B chain

2

20

High-throughput

0.571

High

1006996

TCPB
T-complex protein 1 subunit beta

2

19

High-throughput

0.571

High

1097110

TCPH
T-complex protein 1 subunit eta

2

19

High-throughput

0.571

High

1097108

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.553

High

894715

EMD
Emerin

2

0

High-throughput

0.547

High

558092

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.541

High

990175

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.541

High

501976

H2AZ
Histone H2A.Z

1

6

High-throughput

0.536

High

601650

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

730560

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

1097090

CBX3
Chromobox protein homolog 3

1

6

High-throughput

0.536

High

1097122

BCLF1
Bcl-2-associated transcription factor 1

1

6

High-throughput

0.536

High

1097123

H2AW
Core histone macro-H2A.2

1

4

High-throughput

0.536

High

1097126

TR150
Thyroid hormone receptor-associated protein 3

1

9

High-throughput

0.536

High

346994

BAG2
BAG family molecular chaperone regulator 2

2

2

High-throughput

0.521

High

996678

TBA1B
Tubulin alpha-1B chain

2

20

High-throughput

0.521

High

1024340

S25A3
Solute carrier family 25 member 3

2

12

High-throughput

0.521

High

1040114

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

2

9

High-throughput

0.521

High

1097099

RL22L
Ribosomal protein eL22-like

2

1

High-throughput

0.521

High

1097114

GHC2
Mitochondrial glutamate carrier 2

2

9

High-throughput

0.521

High

1097117

GHC1
Mitochondrial glutamate carrier 1

2

9

High-throughput

0.521

High

542490

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

915438

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.513

High

162938

TERT
Telomerase reverse transcriptase

1

2

High-throughput

0.501

High

179718

MDM4
Protein Mdm4

1

3

High-throughput

0.501

High

371923

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.501

High

413746

P53
Cellular tumor antigen p53

1

4

High-throughput

0.501

High

571193

HGF
Hepatocyte growth factor

1

4

High-throughput

0.501

High

693300

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

13

High-throughput

0.501

High

767190

MERL
Merlin

1

10

High-throughput

0.501

High

842740

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

20

High-throughput

0.501

High

1097094

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.501

High

1097097

HIF1A
Hypoxia-inducible factor 1-alpha

1

13

High-throughput

0.501

High

859812

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.494

High

424401

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.489

High

1097104

LS14A
Protein LSM14 homolog A

1

3

High-throughput

0.489

High

340633

STABP
STAM-binding protein

1

0

High-throughput

0.486

High

543573

ERR1
Steroid hormone receptor ERR1

1

20

High-throughput

0.481

High

445857

ENOA
Alpha-enolase

1

3

Small-scale

0.479

High

474647

VIME
Vimentin

1

8

High-throughput

0.470

High

1097102

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

2

High-throughput

0.464

High

591291

CD44
CD44 antigen

1

4

High-throughput

0.457

High

1097091

GRM1
Metabotropic glutamate receptor 1

1

1

High-throughput

0.457

High

1097093

BECN1
Beclin-1

1

3

High-throughput

0.457

High

1097106

TSC1
Hamartin

1

20

High-throughput

0.457

High

1097124

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.457

High

877478

HSP77
Putative heat shock 70 kDa protein 7

1

20

High-throughput

0.445

High

721714

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.437

High

1097121

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

9

Small-scale

0.437

High

1097116

PAAT
ATPase PAAT

2

0

High-throughput

0.328

High

1097098

CC036
Uncharacterized protein C3orf36

2

0

High-throughput

0.316

High

1097107

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1097127

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.279

Low

1097105

CR032
UPF0729 protein C18orf32

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025