HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: SREK1 (Q8WXA9)
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)
Gene: SREK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 33961781, 14559993
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 508
+	Hs
		952059 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		964037 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1031403 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		516607 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1246388 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		THOC2_HUMAN (46-508): 6.09e-18: 89.8: 12.45
+	At
		790118 PABP2_ARATH (2-105): 1.31e-18: 86.7: 19.23		CID12_ARATH (20-147): 3.84e-22: 99.4: 29.69
+	At
		790115 PABP2_ARATH (2-105): 1.31e-18: 86.7: 19.23		CID8_ARATH (20-152): 8.54e-16: 80.2: 28.36
+	At
		983454 PABP5_ARATH (7-98): 2.49e-15: 77.1: 30.44		CID8_ARATH (20-152): 8.54e-16: 80.2: 28.36