HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	35271311, 32707033, 36736316, 33961781, 36931259, 14676191, 28514442, 15161933, 16306228, 15324659
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification, far western blotting
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006468 - protein phosphorylation GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 788
+	Mm
		910234 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK2_MOUSE (1-788): 0: 764: 96.57
+	Hs
		647869 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Mm
		926780 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MARK3_MOUSE (3-788): 0: 653: 59.90
+	Hs
		647862 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Mm
		910231 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK3_MOUSE (3-788): 0: 653: 59.90
+	Hs
		927600 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Mm
		910318 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK1_MOUSE (3-788): 0: 642: 64.21
+	Hs
		927411 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK4_HUMAN (3-788): 0: 572: 48.20
+	Mm
		910308 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK4_MOUSE (3-788): 0: 572: 48.33
+	Hs
		927047 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		909567 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		927511 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK2_HUMAN (34-733): 3.78e-144: 448: 31.08
+	Hs
		883215 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK1_HUMAN (31-679): 4.27e-140: 434: 32.98
+	Hs
		883214 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		SIK1_HUMAN (31-679): 4.27e-140: 434: 32.98
+	Rn
		871214 1433E_RAT (2-241): 9.9e-144: 403: 68.18		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00
+	Mm
		910272 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		BRSK2_MOUSE (34-481): 8.59e-138: 426: 36.60
+	Hs
		926993 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AAPK1_HUMAN (31-560): 4.31e-139: 424: 30.37
+	Hs
		909507 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AAPK1_HUMAN (31-560): 4.31e-139: 424: 30.37
+	Hs
		927683 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK3_HUMAN (50-361): 5.13e-110: 366: 58.44
+	Mm
		926816 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		SIK3_MOUSE (50-361): 1.03e-108: 363: 57.81