HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	25959826, 36931259, 32814053, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 815
+	Hs
		927216 1433E_HUMAN (3-243): 4.41e-144: 405: 65.43		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		927221 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		690852 1433T_HUMAN (3-244): 3.25e-127: 361: 81.82		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Mm
		927667 1433E_MOUSE (3-243): 4.41e-144: 405: 65.43		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Mm
		927686 1433Z_MOUSE (3-244): 3.15e-142: 399: 88.02		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Mm
		928010 1433B_MOUSE (1-246): 5.58e-141: 396: 98.78		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Hs
		927214 1433G_HUMAN (3-246): 1.92e-109: 317: 75.40		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		927248 1433F_HUMAN (4-244): 2.72e-107: 311: 75.51		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		730466 1433S_HUMAN (3-239): 3.4e-100: 293: 68.62		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Mm
		927697 1433T_MOUSE (3-244): 9.41e-127: 360: 81.82		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Mm
		927664 1433G_MOUSE (3-246): 1.92e-109: 317: 75.40		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Mm
		927700 1433F_MOUSE (4-244): 8.71e-108: 312: 75.51		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Mm
		267034 1433S_MOUSE (3-234): 1.39e-97: 286: 68.38		ATX1_MOUSE (1-815): 0: 1271: 86.89
+	Hs
		505523 1433B_HUMAN (1-246): 3.49e-144: 404: 100.00		ATX1L_HUMAN (1-815): 3.56e-108: 348: 27.15
+	Hs
		505519 1433T_HUMAN (3-244): 3.25e-127: 361: 81.82		ATX1L_HUMAN (1-815): 3.56e-108: 348: 27.15
+	Hs
		505547 1433F_HUMAN (4-244): 2.72e-107: 311: 75.51		ATX1L_HUMAN (1-815): 3.56e-108: 348: 27.15