HitPredict

Interactor 1: H2AY (O75367)
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)
Gene: MACROH2A1

Interactor 2: RN168 (Q8IYW5)
E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)
Gene: RNF168

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32424115
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~Prok-RING_4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0040029 - epigenetic regulation of gene expression
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 369 Hs			1 571
+	Hs
		591726 H2AX_HUMAN (1-142): 1.08e-65: 206: 60.69		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		1232693 H2A2A_HUMAN (1-126): 8.21e-65: 203: 63.57		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		1272803 H2A3_HUMAN (1-126): 8.96e-65: 203: 62.79		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		419077 H2A1B_HUMAN (1-126): 1.28e-64: 203: 62.02		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		502425 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		1162827 H2A2C_HUMAN (1-125): 9.27e-64: 201: 63.28		RN168_HUMAN (1-571): 4.72e-101: 319: 100.00
+	Hs
		1232698 H2A2A_HUMAN (1-126): 8.21e-65: 203: 63.57		RN169_HUMAN (12-435): 4.66e-41: 160: 24.39
+	Hs
		419092 H2A1B_HUMAN (1-126): 1.28e-64: 203: 62.02		RN169_HUMAN (12-435): 4.66e-41: 160: 24.39
+	Hs
		1162838 H2A2C_HUMAN (1-125): 9.27e-64: 201: 63.28		RN169_HUMAN (12-435): 4.66e-41: 160: 24.39
+	Hs
		1370944 H2A1H_HUMAN (1-125): 1.08e-64: 203: 62.50		PRG4_HUMAN (4-544): 1.1e-10: 66.9: 9.23
+	Hs
		1361895 H2A1H_HUMAN (1-125): 1.08e-64: 203: 62.50		TITIN_HUMAN (5-562): 6.37e-09: 61.5: 7.91
+	Hs
		419108 H2A1B_HUMAN (1-126): 1.28e-64: 203: 62.02		TITIN_HUMAN (5-562): 6.37e-09: 61.5: 7.91
+	Hs
		502455 H2A1_HUMAN (1-126): 1.21e-64: 203: 62.02		TITIN_HUMAN (5-562): 6.37e-09: 61.5: 7.91