HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11117529
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding GO:0043433 - negative regulation of DNA-binding transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 621 Hs			1 595
+	Hs
		370843 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		277875 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		278312 PIAS2_HUMAN (1-621): 0: 811: 100.00		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		278207 PIAS2_HUMAN (1-621): 0: 811: 100.00		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		278228 PIAS2_HUMAN (1-621): 0: 811: 100.00		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		1270069 PIAS3_HUMAN (1-621): 0: 666: 55.25		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		278138 PIAS1_HUMAN (1-621): 0: 653: 54.10		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		277974 PIAS1_HUMAN (1-621): 0: 653: 54.10		HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58
+	Hs
		277876 PIAS1_HUMAN (1-621): 0: 653: 54.10		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		611538 PIAS3_HUMAN (1-621): 0: 666: 55.25		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		278072 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR1H3_HUMAN (99-548): 6.2e-112: 343: 20.49
+	Hs
		277936 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		278210 PIAS2_HUMAN (1-621): 0: 811: 100.00		PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14
+	Hs
		278004 PIAS1_HUMAN (1-621): 0: 653: 54.10		NR1H2_HUMAN (103-548): 4.02e-105: 326: 21.26
+	Hs
		277964 PIAS1_HUMAN (1-621): 0: 653: 54.10		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		278213 PIAS2_HUMAN (1-621): 0: 811: 100.00		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		414536 PIAS3_HUMAN (1-621): 0: 666: 55.25		PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14
+	Hs
		277885 PIAS1_HUMAN (1-621): 0: 653: 54.10		PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14
+	Hs
		487883 PIAS3_HUMAN (1-621): 0: 666: 55.25		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		277899 PIAS1_HUMAN (1-621): 0: 653: 54.10		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16