HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.642

Property	Details
Experiments	24623722, 29568061, 34079125
Identification Methods	two hybrid, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 664
+	Hs
		277871 PIAS1_HUMAN (1-621): 0: 653: 54.10		K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71
+	Hs
		278225 PIAS2_HUMAN (1-621): 0: 811: 100.00		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		278216 PIAS2_HUMAN (1-621): 0: 811: 100.00		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		278222 PIAS2_HUMAN (1-621): 0: 811: 100.00		DESM_HUMAN (27-389): 6.1e-28: 119: 30.03
+	Hs
		277872 PIAS1_HUMAN (1-621): 0: 653: 54.10		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		277932 PIAS1_HUMAN (1-621): 0: 653: 54.10		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		360149 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		443652 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		422232 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		NFL_HUMAN (28-433): 1.96e-26: 115: 27.07