Protein: NR1H3
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)

Gene: NR1H3
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q13133

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

873154

RXRG
Retinoic acid receptor RXR-gamma

7

20

High-throughput

0.970

High

704526

RXRB
Retinoic acid receptor RXR-beta

6

20

High-throughput

0.955

High

625807

RXRA
Retinoic acid receptor RXR-alpha

4

20

Small-scale

0.891

High

1060602

PPARA
Peroxisome proliferator-activated receptor alpha

3

19

Small-scale

0.879

High

1095500

NCOA1
Nuclear receptor coactivator 1

3

20

Small-scale

0.850

High

1095498

NR0B2
Nuclear receptor subfamily 0 group B member 2

2

18

Small-scale

0.815

High

1095511

MDFI
MyoD family inhibitor

4

3

High-throughput

0.709

High

278329

NCOR1
Nuclear receptor corepressor 1

4

20

Small-scale

0.698

High

789486

PPARG
Peroxisome proliferator-activated receptor gamma

1

19

Small-scale

0.692

High

1041747

PPARD
Peroxisome proliferator-activated receptor delta

1

20

Small-scale

0.692

High

404025

GCR
Glucocorticoid receptor

1

20

Small-scale

0.621

High

1095520

NCOA3
Nuclear receptor coactivator 3

1

20

High-throughput

0.621

High

461425

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468322

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

1095496

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.618

High

228581

STRN
Striatin

2

20

High-throughput

0.611

High

1092870

STRN3
Striatin-3

2

20

High-throughput

0.611

High

1095503

DDI2
Protein DDI1 homolog 2

2

10

High-throughput

0.611

High

1095514

STRN4
Striatin-4

2

20

High-throughput

0.611

High

347671

BAG3
BAG family molecular chaperone regulator 3

2

2

High-throughput

0.606

High

1095510

BARD1
BRCA1-associated RING domain protein 1

2

20

Small-scale

0.584

High

216424

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

20

High-throughput

0.573

High

246571

KDM1A
Lysine-specific histone demethylase 1A

1

18

High-throughput

0.573

High

258453

EDF1
Endothelial differentiation-related factor 1

1

3

Small-scale

0.573

High

1067256

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.571

High

350456

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

13

High-throughput

0.553

High

273997

CREST
Calcium-responsive transactivator

1

20

High-throughput

0.541

High

1095502

AKIR2
Akirin-2

1

1

High-throughput

0.536

High

1095513

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.518

High

537080

HSP7C
Heat shock cognate 71 kDa protein

1

18

High-throughput

0.515

High

385703

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.515

High

843526

HD
Huntingtin

1

4

High-throughput

0.515

High

1095505

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

8

High-throughput

0.515

High

252966

PDE8A
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

1

0

High-throughput

0.513

High

422029

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

993540

UBC9
SUMO-conjugating enzyme UBC9

1

10

Small-scale

0.501

High

1095499

MED1
Mediator of RNA polymerase II transcription subunit 1

1

20

Small-scale

0.501

High

1095504

CE350
Centrosome-associated protein 350

1

13

Small-scale

0.501

High

1095519

NCOR2
Nuclear receptor corepressor 2

1

20

Small-scale

0.501

High

1095507

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

13

High-throughput

0.494

High

653286

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.489

High

219727

FOXO3
Forkhead box protein O3

1

20

High-throughput

0.481

High

555672

ACTN1
Alpha-actinin-1

1

12

High-throughput

0.481

High

873952

NRIP1
Nuclear receptor-interacting protein 1

1

19

High-throughput

0.481

High

968898

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.481

High

1095497

NCOA6
Nuclear receptor coactivator 6

1

20

High-throughput

0.481

High

1095501

ZXDC
Zinc finger protein ZXDC

1

5

High-throughput

0.481

High

1095508

KAT2B
Histone acetyltransferase KAT2B

1

20

High-throughput

0.481

High

1095516

ING3
Inhibitor of growth protein 3

1

11

High-throughput

0.481

High

129037

MEN1
Menin

1

9

Small-scale

0.479

High

219166

LTOR5
Ragulator complex protein LAMTOR5

1

2

Small-scale

0.479

High

297594

PIAS1
E3 SUMO-protein ligase PIAS1

1

15

Small-scale

0.479

High

664726

CCND1
G1/S-specific cyclin-D1

1

8

Small-scale

0.479

High

838080

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.479

High

940943

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.479

High

946099

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.479

High

1037790

IRF8
Interferon regulatory factor 8

1

1

Small-scale

0.479

High

1095509

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

20

Small-scale

0.479

High

1095512

AASD1
Alanyl-tRNA editing protein Aarsd1

1

3

High-throughput

0.479

High

1095517

FKBPL
FK506-binding protein-like

1

12

High-throughput

0.479

High

1095518

MKLN1
Muskelin

1

10

High-throughput

0.479

High

109397

G5E9A7
DM1 locus, WD repeat containing

1

20

High-throughput

0.470

High

1095506

BBS5
BBSome complex member BBS5

1

0

Small-scale

0.458

High

1095515

T161A
Transmembrane protein 161A

1

3

High-throughput

0.439

High

76519

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

4

High-throughput

0.437

High


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Last updated: 11Aug2025