HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	28680062
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 2442
+	Hs
		1270855 PIAS3_HUMAN (1-621): 0: 666: 55.25		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		278139 PIAS1_HUMAN (1-621): 0: 653: 54.10		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		999269 PIAS3_HUMAN (1-621): 0: 666: 55.25		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		278068 PIAS1_HUMAN (1-621): 0: 653: 54.10		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		170420 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		1067047 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	At
		1147337 SIZ1_ARATH (5-521): 5.9e-109: 349: 21.94		GTE3_ARATH (1093-1371): 1.09e-52: 195: 18.41
+	At
		1147329 SIZ1_ARATH (5-521): 5.9e-109: 349: 21.94		GTE5_ARATH (964-1370): 5.66e-43: 167: 15.60